Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study

The Journal of Infectious Diseases
Ted CohenDouglas Wilson

Abstract

The clinical management of tuberculosis is a major challenge in southern Africa. The prevalence of within-host genetically heterogeneous Mycobacterium tuberculosis infection and its effect on treatment response are not well understood. We enrolled 500 patients with tuberculosis in KwaZulu-Natal and followed them through 2 months of treatment. Using mycobacterial interspersed repetitive units-variable number of tandem repeats genotyping to identify mycobacterial heterogeneity, we report the prevalence and evaluate the association of heterogeneity with treatment response. Upon initiation of treatment, 21.1% of participants harbored a heterogeneous M. tuberculosis infection; such heterogeneity was independently associated with a nearly 2-fold higher odds of persistent culture positivity after 2 months of treatment (adjusted odds ratio, 1.90; 95% confidence interval, 1.03-3.50).

References

Jun 11, 2005·American Journal of Respiratory and Critical Care Medicine·Annelies van RieRobin M Warren
Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Pérez-LagoD García-de-Viedma
May 15, 2015·Journal of Clinical Microbiology·Amanda C BrownJudith Breuer

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Citations

Jan 26, 2017·Scientific Reports·Mansour Kargarpour KamakoliSeyed Davar Siadat
Nov 27, 2018·Open Forum Infectious Diseases·Douglas WilsonGary Maartens
Jan 30, 2018·Frontiers in Immunology·Helder Novais BastosMargarida Saraiva
Oct 12, 2018·Microbial Genomics·Michael A MartinWilliam P Hanage
Oct 25, 2020·BMC Infectious Diseases·Patrick George Tobias CudahyTed Cohen
Jan 8, 2021·Frontiers in Genetics·Alexander Stephen ByrneKapil Tahlan
Dec 5, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Michael Asare-BaahMichael Lauzardo
Jan 13, 2021·The Journal of Infectious Diseases·Yiwang ChenQian Gao
Jan 13, 2021·BMC Infectious Diseases·Zeeba Zahra SultanaAhmed Hossain
Apr 7, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Mansour Kargarpour KamakoliFarzam Vaziri
Sep 2, 2021·The Journal of Infectious Diseases·Yiwang ChenQian Gao

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