Within-host population dynamics and the evolution of microparasites in a heterogeneous host population

Evolution; International Journal of Organic Evolution
Vitaly V GanusovRustom Antia

Abstract

Why do parasites harm their hosts? The general understanding is that if the transmission rate and virulence of a parasite are linked, then the parasite must harm its host to maximize its transmission. The exact nature of such trade-offs remains largely unclear, but for vertebrate hosts it probably involves interactions between a microparasite and the host immune system. Previous results have suggested that in a homogeneous host population in the absence of super- or coinfection, within-host dynamics lead to selection of the parasite with an intermediate growth rate that is just being controlled by the immune system before it kills the host (Antia et al. 1994). In this paper, we examine how this result changes when heterogeneity is introduced to the host population. We incorporate the simplest form of heterogeneity--random heterogeneity in the parameters describing the size of the initial parasite inoculum, the immune response of the host, and the lethal density at which the parasite kills the host. We find that the general conclusion of the previous model holds: parasites evolve some intermediate growth rate. However, in contrast with the generally accepted view, we find that virulence (measured by the case mortality or the rat...Continue Reading

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Citations

Sep 2, 2003·Theoretical Population Biology·Vitaly V Ganusov, Rustom Antia
Jun 5, 2003·Trends in Microbiology·Sylvain Gandon, Troy Day
Mar 1, 2011·Journal of Biological Dynamics·Andrea Pugliese
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