Within-person across-neuropsychological test variability and incident dementia.

JAMA : the Journal of the American Medical Association
Roee HoltzerRichard Lipton

Abstract

Neuropsychological tests are used to predict and diagnose dementia. However, to our knowledge, no studies to date have examined whether within-person across-neuropsychological test variability predicts dementia. To examine whether within-person across-neuropsychological test variability predicts future dementia. The Einstein Aging Study (EAS) is a population-based longitudinal study of aging and dementia located in Bronx County, New York. We used Cox proportional hazards models using age as the time scale to estimate hazard ratios (HRs) for performance on individual neuropsychological tests (Free and Cued Selective Reminding Test, Digit Symbol Substitution subtest of the Wechsler Adult Intelligence Scale Revised, and the Vocabulary subtest of the Wechsler Adult Intelligence Scale Revised) and for within-person across-neuropsychological test variability as predictors of incident dementia. Analyses were stratified by sex, and controlled for education and medical illness. A total of 1797 participants (age > or = 70 years) enrolled in the EAS between October 1993 and December 2007. Participants seen for the baseline visit only (n = 750), prevalent dementia cases (n = 72), and those with missing follow-up information (n = 78) were e...Continue Reading

References

Apr 1, 1989·Annals of Neurology·R KatzmanW L Ooi
Jun 1, 1988·Neurology·E GroberR Dresner
Jul 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·G BlessedM Roth
Jul 1, 1996·Brain and Cognition·S E McPherson, J L Cummings
Feb 16, 2000·Neurobiology of Aging·E GroberR B Lipton
Jul 19, 2001·Journal of the International Neuropsychological Society : JINS·M S AlbertK Jones
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Oct 24, 2002·Acta Psychiatrica Scandinavica·J BischkopfM C Angermeyer
Nov 9, 2002·Journal of Clinical and Experimental Neuropsychology·Alexander CollieJon Currie
Nov 29, 2002·The New England Journal of Medicine·Joe VergheseHerman Buschke
Jul 24, 2003·Brain : a Journal of Neurology·Donald T StussMichael P Alexander
Sep 27, 2003·Journal of the American Geriatrics Society·Richard B LiptonHerman Buschke
Nov 25, 2003·Journal of the International Neuropsychological Society : JINS·David J SchretlenGodfrey D Pearlson
Dec 5, 2003·Gerontology·Matthias Kliegel, Martin Sliwinski
Oct 27, 2004·Age and Ageing·Joe VergheseRichard B Lipton
Dec 8, 2004·Statistics in Medicine·Anne C M Thiébaut, Jacques Bénichou
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Aug 3, 2005·Neuropsychology·Lars BäckmanBrent J Small
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·H JokinenT Erkinjuntti
Apr 6, 2006·Neuropsychology·Roee HoltzerRichard B Lipton
Jan 24, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Joe VergheseXiaonan Xue
Sep 6, 2007·Neuropsychology·Roee HoltzerJoe Verghese

❮ Previous
Next ❯

Citations

Nov 13, 2013·Annual Review of Psychology·Amanda R RabinowitzHarvey S Levin
Apr 5, 2014·Visual Neuroscience·Jeannette R MahoneyRoee Holtzer
Nov 29, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roee HoltzerJoe Verghese
Jun 29, 2014·Gait & Posture·Clara LiRoee Holtzer
Jan 24, 2014·Current Gerontology and Geriatrics Research·Leslie VaughanMark A Espeland
Jul 29, 2010·Journal of the International Neuropsychological Society : JINS·Jeannette R MahoneyRoee Holtzer
Dec 4, 2010·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Roee HoltzerJoe Verghese
Mar 19, 2011·Journal of Clinical and Experimental Neuropsychology·Bonnie P WhiteheadStuart W S MacDonald
Jul 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joe VergheseCuiling Wang
May 26, 2010·Nature Reviews. Neurology·Blossom C M StephanCarole Dufouil
Jun 7, 2013·Aging Clinical and Experimental Research·Mooyeon Oh-ParkJoe Verghese
Apr 28, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laurence M BinderBrian L Brooks
Aug 29, 2012·Schizophrenia Bulletin·David R RoalfRaquel E Gur
Aug 8, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gilles AllaliJoe Verghese
Jan 25, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Denis A EvansSandra Weintraub
Dec 1, 2015·Journal of Clinical and Experimental Neuropsychology·Nathalie MellaAnik de Ribaupierre
Jul 2, 2011·Journal of the American Geriatrics Society·Mooyeon Oh-ParkJoe Verghese
Jul 22, 2010·Journal of the American Geriatrics Society·Mooyeon Oh-ParkJoe Verghese
Feb 28, 2013·Annals of Neurology·Jared P ReisKristine Yaffe
Jan 14, 2010·International Journal of Geriatric Psychiatry·Alyssa A GamaldoKeith E Whitfield
Dec 3, 2011·Archives of Physical Medicine and Rehabilitation·Mooyeon Oh-ParkJoe Verghese
Aug 26, 2015·Brain Imaging and Behavior·Lindsay J HinesUNKNOWN Multicenter AIDS Cohort Study
Nov 15, 2012·Schizophrenia Research·David R RoalfRuben C Gur
Jul 9, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ronald J GurreraJennifer Moye
Sep 11, 2014·Biological Psychology·Colette M SmartStuart W S MacDonald
Mar 18, 2015·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Céline Tanner-EggenKlemens Gutbrod
Jul 24, 2012·Brain Research·Jeannette R MahoneyRoee Holtzer
Oct 26, 2011·Brain Research·Jeannette R MahoneyRoee Holtzer
Jul 30, 2014·Frontiers in Aging Neuroscience·Andrea M KälinChristoph Hock
Aug 5, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Eric D AndersonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·David R RoalfUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 20, 2016·International Journal of Methods in Psychiatric Research·Pierre SchweitzerJoel Swendsen
Aug 28, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roee HoltzerCuiling Wang
Sep 8, 2016·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Chelsea B Schoen, Roee Holtzer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.