Within-session sensitization and between-session habituation: a robust physiological response to repetitive painful heat stimulation

European Journal of Pain : EJP
Arne MayT P Jürgens

Abstract

Habituation and sensitization are important behavioural responses to repeated exposure of painful stimuli. Whereas within-session response dynamics to nociceptive stimuli is well characterized, little is known about long-term behaviour due to repetitive nociceptive stimulation. We used a standardized longitudinal heat pain paradigm in 66 healthy participants, 21 patients with chronic low back pain and 22 patients with depression who received daily sessions of 60 suprathreshold heat stimuli (48 °C each) for eight consecutive days. All three groups showed the same response: Repeated painful stimulation over several days resulted in substantially decreased pain ratings to identical painful stimuli. The decreased perception of pain over time was associated with a very robust increase in pain ratings in each single pain session, i.e., all participants sensitized within sessions and habituated between sessions. This uniform pattern was equally present in all examined groups. Chronic pain and depression do not seem to interfere with short-term sensitization and long-term habituation in this model of repetitive phasic heat pain.

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Citations

Apr 29, 2014·The Journal of Pain : Official Journal of the American Pain Society·Marieke JepmaTor D Wager
Jan 10, 2016·Neuron·Igor Elman, David Borsook
Sep 10, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Yenisel Cruz-Almeida, Roger B Fillingim
Jul 17, 2015·Pain Practice : the Official Journal of World Institute of Pain·Florian T NickelChristian Maihöfner
Dec 21, 2014·Brain Imaging and Behavior·Isabel Ellerbrock, Arne May
Jun 6, 2015·The Journal of Pain : Official Journal of the American Pain Society·Katharina SchmidtUlrike Bingel
Mar 16, 2013·Pain·Marieke Jepma, Tor D Wager
May 29, 2012·Pain·Veit MyliusJean-Pascal Lefaucheur
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Oct 13, 2017·Cephalalgia : an International Journal of Headache·Elena Lozano-SotoAntonio Oliviero
Jul 3, 2019·Scientific Reports·E J HirdD Talmi
Mar 13, 2012·European Journal of Pain : EJP·M BreimhorstF Birklein
Feb 4, 2021·European Journal of Pain : EJP·Tibor M SzikszayKerstin Luedtke

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