Wittig olefination between phosphine, aldehyde, and allylic carbonate: a general method for stereoselective synthesis of trisubstituted 1,3-dienes with highly variable substituents

Organic Letters
Rong ZhouZhengjie He

Abstract

A clean and salt-free Wittig olefination between phosphines, aldehydes, and allylic carbonates is described. It represents a general method for convenient and efficient synthesis of 1,2,4-trisubstituted 1,3-dienes from readily available starting materials. This method exhibits high synthetic efficiency, high stereoselectivity, and high variability of substituent.

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Jul 3, 2018·Organic & Biomolecular Chemistry·Neng-Jun ZhongLi Liu
May 16, 2013·Chemical Society Reviews·Peter A Byrne, Declan G Gilheany
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Nov 5, 2020·Organic & Biomolecular Chemistry·Masanori ShigenoYoshinori Kondo
Jan 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raquel G Soengas, Humberto Rodríguez-Solla
Feb 29, 2020·The Journal of Organic Chemistry·Wen-Biao WuJian Zhou
Sep 28, 2018·Chemical Reviews·Hongchao GuoOhyun Kwon

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