Abstract
LINGO-1 is a transmembrane receptor expressed primarily in the central nervous system (CNS) and plays an important role in myelination. Recent studies have indicated that it is also involved in oligodendrocyte precursor cell (OPC) survival and differentiation; however, the downstream signaling pathway underlying OPC development is unknown. In our previous study, we found that LINGO-1 is associated with WNK1 in mediating Nogo-induced neurite extension inhibition by RhoA activation. In an effort to identify the role of LINGO-1-WNK1 in OPCs, we first confirmed that WNK1 is also expressed in OPCs and co-localized with LINGO-1, which suppresses WNK1 expression by RNA interference-attenuated Nogo66-induced inhibition of OPC differentiation. Furthermore, we mapped the WNK1 kinase domain using several fragmented peptides to identify the key region of interaction with LINGO-1. We found that a sequence corresponding to the D6 peptide is necessary for the interaction. Finally, we found that using the TAT-D6 peptide to introduce D6 peptide into primary cultured OPC inhibits the association between LINGO-1 and WNK1 and significantly attenuates Nogo66-induced inhibition of OPC differentiation. Taken together, our results show that WNK1, via ...Continue Reading
References
Dec 1, 1992·Annals of Neurology·H F McFarlandD E McFarlin
Jan 1, 1997·Brain : a Journal of Neurology·N D Jeffery, W F Blakemore
Apr 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·R J Franklin, W F Blakemore
Sep 28, 1999·Glia·S A ShieldsR J Franklin
Sep 5, 2002·Nature Reviews. Neuroscience·Robin J M Franklin
Feb 18, 2004·Nature Neuroscience·Sha MiR Blake Pepinsky
Mar 17, 2004·Molecular and Cellular Neurosciences·Rachel H WoodruffRobin J M Franklin
Nov 24, 2004·Molecular and Cellular Neurosciences·Jean Christophe DeloulmeJacques Baudier
May 17, 2005·Nature Neuroscience·Sha MiR Blake Pepinsky
Oct 6, 2005·Neuron·Monique Dubois-DalcqRobin J M Franklin
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark R KotterRobin J M Franklin
Jan 19, 2006·Journal of Cell Science·Xiaohui XuYizhang Chen
Jan 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xinhua LeeSha Mi
Jul 17, 2007·Neuroscience Letters·Qiang GuoBingyin Su
Oct 2, 2007·Nature Medicine·Sha MiWutian Wu
Jun 3, 2008·Brain : a Journal of Neurology·T KuhlmannW Brück
Apr 14, 2009·The Journal of Biological Chemistry·Zhaohuan ZhangCheng He
May 19, 2009·Neuroscience Letters·Xiao-Hui XuCheng He
Apr 20, 2011·The Journal of Cell Biology·Céline CaillavaAnne Baron-Van Evercooren
Jun 23, 2011·Annual Review of Neuroscience·Stephen P J FancyDavid H Rowitch
Jan 10, 2012·Brain Research·Jing-Ya HuangPei-Hua Lu
Mar 14, 2013·The Journal of Biological Chemistry·Zhaohuan ZhangCheng He
Mar 4, 2014·Molecular and Cellular Neurosciences·Xinhua LeeSha Mi
Mar 26, 2014·Cell Research·Xiao-Hui XuZhen-Ge Luo
Apr 12, 2014·Neuroscience·J J Boulanger, C Messier
Apr 18, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heung Sun KwonStanislav I Tomarev
Citations
Jul 28, 2016·Brain Sciences·Han LiuHuangui Xiong
Jan 10, 2019·Glia·Stefanie AlbrechtPetra Hundehege
Feb 1, 2018·Neurochemical Research·Xiao-Jie SongLi Jiang
Jun 18, 2017·Neurochemical Research·Zhao-Huan ZhangXiao-Hui Xu
Jan 14, 2020·MAbs·Karl J M HanfR Blake Pepinsky
Jan 31, 2017·Cellular and Molecular Neurobiology·Zhao-Huan ZhangXiao-Hui Xu
Dec 1, 2018·BMC Neurology·Behrouz RahmaniSareh Asadi
Oct 19, 2017·Scientific Reports·Chantal Hoi Yin CheungHsueh-Fen Juan
Oct 3, 2017·Neural Regeneration Research·Simon FoaleZubair Ahmed
Apr 26, 2020·Scientific Reports·Zhao-Huan ZhangXiao-Hui Xu
Apr 20, 2021·Neuroscience Letters·Kuibin Xu, Ying Zhang
May 4, 2021·Frontiers in Genetics·Chen HuangLiren Liu
Jun 22, 2021·Experimental and Therapeutic Medicine·Hui YangHongbin Li