Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo

Developmental Biology
E J JinL W Burrus

Abstract

Recent studies show that specification of some neural crest lineages occurs prior to or at the time of migration from the neural tube. We investigated what signaling events establish the melanocyte lineage, which has been shown to migrate from the trunk neural tube after the neuronal and glial lineages. Using in situ hybridization, we find that, although Wnts are expressed in the dorsal neural tube throughout the time when neural crest cells are migrating, the Wnt inhibitor cfrzb-1 is expressed in the neuronal and glial precursors and not in melanoblasts. This expression pattern suggests that Wnt signaling may be involved in specifying the melanocyte lineage. We further report that Wnt-3a-conditioned medium dramatically increases the number of pigment cells in quail neural crest cultures while decreasing the number of neurons and glial cells, without affecting proliferation. Conversely, BMP-4 is expressed in the dorsal neural tube throughout the time when neural crest cells are migrating, but is decreased coincident with the timing of melanoblast migration. This expression pattern suggests that BMP signaling may be involved in neural and glial cell differentiation or repression of melanogenesis. Purified BMP-4 reduces the numbe...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C KalcheimA Rosenthal
Jan 1, 1992·Developmental Biology·K B Artinger, M Bronner-Fraser
Jun 1, 1981·Experimental Cell Research·M Sieber-BlumK M Yamada
Aug 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J E VarleyG D Maxwell
Feb 1, 1994·Journal of Neurobiology·M F MarusichJ A Weston
Jul 1, 1995·Mechanisms of Development·M HollydayA P McMahon
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A Selleck, M Bronner-Fraser
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A RattnerJ Nathans
May 1, 1997·Developmental Biology·J A Rudnicki, A M Brown
Jul 18, 1997·Biochemical and Biophysical Research Communications·S WangM Moos
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·K LinF P Luyten
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·J P Saint-JeannetI B Dawid
Mar 7, 1998·Developmental Biology·J CapdevilaR L Johnson
Mar 14, 1998·Developmental Biology·C Chang, A Hemmati-Brivanlou
Jul 23, 1998·Current Topics in Developmental Biology·C A Erickson, M V Reedy
Jan 20, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S ShibamotoS Takada
Jul 7, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M Sieber-Blum
Aug 13, 1999·Development, Growth & Differentiation·Y KawakamiT Nohno
Sep 24, 1999·Mechanisms of Development·A P MonaghanC Niehrs
Nov 24, 1999·Mechanisms of Development·D DuprezN Le Douarin
Feb 5, 2000·Developmental Biology·R K LadherP H Francis-West
Apr 5, 2000·The Journal of Biological Chemistry·K TakedaS Shibahara
May 24, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P D HenionJ A Weston
Aug 1, 2000·The Journal of Biological Chemistry·A G RidgewayI S Skerjanc
Aug 30, 2000·Proceedings of the National Academy of Sciences of the United States of America·K J DunnW J Pavan
Oct 12, 2000·Mechanisms of Development·P EsteveP Bovolenta

❮ Previous
Next ❯

Citations

May 14, 2005·Anatomy and Embryology·Corina Schmidt, Ketan Patel
Jan 22, 2003·Biochemical and Biophysical Research Communications·Gerard BainJackie Papkoff
Mar 26, 2003·Developmental Biology·Ronelle J Hall, Carol A Erickson
Jul 9, 2002·Current Opinion in Genetics & Development·Manuel J Aybar, Roberto Mayor
Dec 11, 2002·The Journal of Cell Biology·Lisette HariLukas Sommer
Sep 2, 2005·Molecular Biology of the Cell·Lisa A Taneyhill, Marianne Bronner-Fraser
Apr 10, 2008·Human Molecular Genetics·Ivana MateraWilliam J Pavan
Dec 11, 2007·Development, Growth & Differentiation·Atsushi KawaguchiTakahiro Kunisada
Dec 11, 2008·Pigment Cell & Melanoma Research·Aaron J Thomas, Carol A Erickson
Jun 25, 2009·Pigment Cell & Melanoma Research·James A Lister
Feb 12, 2011·Pigment Cell & Melanoma Research·Lukas Sommer
Jun 12, 2012·Pigment Cell & Melanoma Research·Caleb M BaileyPaul M Kulesa
Jun 9, 2012·Molecular Cancer Research : MCR·Jennifer D KubicDeborah Lang
May 14, 2010·Development·Sarah Piloto, Thomas F Schilling
Jun 12, 2008·PloS One·Daisuke KamiAkihiro Umezawa
Feb 19, 2010·Folia Histochemica Et Cytobiologica·Ryszard GalusJarosław Jóźwiak
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuko Mori-AkiyamaBenoit de Crombrugghe
Dec 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrey A SharovVladimir A Botchkarev
Feb 5, 2010·International Journal of Cell Biology·Hee-Young ParkBarbara A Gilchrest
Oct 11, 2003·Current Opinion in Genetics & Development·Nicole M Le Douarin, Elisabeth Dupin
May 11, 2010·Cellular and Molecular Life Sciences : CMLS·Igor Adameyko, Francois Lallemend
Mar 28, 2013·Cellular and Molecular Life Sciences : CMLS·Tarik Regad
May 27, 2015·International Journal of Molecular Sciences·Yuanyuan ZhaoChangsheng Dong
Dec 26, 2015·International Journal of Molecular Sciences·Amber N MullYu-Chieh Wang
Jun 10, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Casto RamosEduardo Soriano
May 3, 2011·Journal of Dermatological Science·Tamihiro KawakamiYoshinao Soma
Dec 27, 2008·Journal of Molecular and Cellular Cardiology·Zhongyan ZhangVictor J Dzau
Dec 14, 2011·The Journal of Investigative Dermatology·Mina Yaar, Hee-Young Park
Aug 13, 2011·The Journal of Investigative Dermatology·Ruifeng YangXiaowei Xu
Oct 26, 2007·The Journal of Investigative Dermatology·Tamihiro KawakamiYoshinao Soma
May 17, 2005·Pigment Cell Research·Karen Joyce DunnWilliam J Pavan
Sep 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Curtis W Balmer, Anthony-Samuel LaMantia
Jan 14, 2004·Pigment Cell Research·Itaru Suzuki, Tomonori Motokawa
May 23, 2012·Genesis : the Journal of Genetics and Development·Rong HanJanice L Brissette
Oct 14, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Toshiyuki YamadaKazuo Araki
Dec 2, 2009·Cell Biology International·Kim DongkyunEun-Jung Jin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.