Wnt/β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma.

Bioscience Reports
Guo-Feng ZhangTong-Jun Liu

Abstract

Cholangiocarcinoma (CCA) is a fatal malignant tumor of biliary epithelial cells involving intra- or extra-hepatic bile ducts. The prognosis of CCA is generally poor due to its diagnosis at the late stages. The currently employed chemotherapeutic agents do not increase the survival rate in patients with unresectable CCA. Accordingly, there is a need to identify new therapeutic agents for the effective management of intra- and extra-hepatic CCA. Clinical as well as preclinical studies have suggested the key role of the activation of Wnt/β-catenin signaling pathway in the induction and progression of CCA. There is an up-regulation of different Wnt ligands including Wnt2, Wnt3, Wnt5, Wnt7 and Wnt10 along with redistribution of β-catenin (more expression in the nucleus and lesser on the cell surface due to nuclear translocation of β-catenin) in different types of malignant biliary tumors. Apart from the role of this pathway in the induction and progression of CCA, this pathway is also involved in inducing multidrug resistance by inducing the expression of P-glycoprotein efflux pump on the cancer cells. These deleterious effects of Wnt/β-catenin signaling are mediated in association with other signaling pathways involving microRNAs (...Continue Reading

References

Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K AshidaN Kaibara
Sep 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K SugimachiM Tsuneyoshi
Sep 27, 2001·Annals of Surgery·W R JarnaginL H Blumgart
Jul 18, 2002·Annals of the New York Academy of Sciences·Giampaolo Tortora, Fortunato Ciardiello
Oct 11, 2005·Lancet·Shahid A KhanSimon D Taylor-Robinson
Mar 22, 2006·Molecular Carcinogenesis·Watcharin LoilomeMasanao Miwa
May 9, 2007·Journal of Neurochemistry·Andrés OzaitaRafael Maldonado
Apr 9, 2010·The New England Journal of Medicine·Juan ValleUNKNOWN ABC-02 Trial Investigators
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Watcharin LoilomePuangrat Yongvanit
Apr 10, 2012·Gastroenterology·Jinqiang ZhangTong Wu
May 25, 2013·International Surgery·Ryohei NomuraOkio Hino
May 31, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kurtis D Davies, Robert C Doebele
Feb 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Watcharin LoilomeGregory J Riggins
Jun 4, 2014·International Journal of Oncology·Sarangerel JachinWoo Sung Moon
Jun 5, 2014·Journal of Hepato-biliary-pancreatic Sciences·Kosei MaemuraSonshin Takao
Dec 5, 2014·Journal of Experimental & Clinical Cancer Research : CR·Shengqiang ZhaoChengyong Qin
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Supak YothaisongWatcharin Loilome
Jan 30, 2015·World Journal of Gastroenterology : WJG·Gui-Li HuangQing-Xi Chen
Feb 18, 2015·The Journal of Clinical Investigation·Luke BoulterStuart J Forbes
Mar 10, 2015·Gastroenterology·Satdarshan Pal Monga
Jul 5, 2015·Molecular Cancer Therapeutics·Tomoki ShirotaTatsuhiro Shibata
Oct 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Randa TaoChristopher H Crane
Apr 1, 2002·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ki Jung YunTae Hyeon Kim
Jul 22, 2016·Cancers·Elke Kaemmerer, Nikolaus Gassler

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