Wnt/β-catenin signaling in adult mammalian epithelial stem cells

Developmental Biology
Kai Kretzschmar, Hans Clevers

Abstract

Adult stem cells self-renew and replenish differentiated cells in various organs and tissues throughout a mammal's life. Over the last 25 years an ever-growing body of knowledge has unraveled the essential regulation of adult mammalian epithelia by the canonical Wnt signaling with its key intracellular effector β-catenin. In this review, we discuss the principles of the signaling pathway and its role in adult epithelial stem cells of the intestine and skin during homeostasis and tumorigenesis. We further highlight the research that led to the identification of new stem cell markers and methods to study adult stem cells ex vivo.

Citations

Nov 20, 2018·Nature Reviews. Gastroenterology & Hepatology·Maria J PerugorriaJesus M Banales
Nov 22, 2017·EMBO Reports·Sumitra TatapudyTodd Nystul
Jan 23, 2020·International Journal of Molecular Sciences·Robert Vignali, Silvia Marracci
Jun 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kim E BoonekampHans Clevers
Oct 2, 2020·Science Advances·Daniel C CorbettKelly R Stevens
Jul 25, 2019·Marine Drugs·Sajee ThaweekitphathanaphakdeeApirada Sucontphunt
Dec 20, 2019·Nature Reviews. Immunology·Yotam E Bar-EphraimHans Clevers
May 3, 2019·Cellular and Molecular Life Sciences : CMLS·Martin KnöflerJoanna James
Nov 6, 2018·Frontiers in Pharmacology·Han ZhangJianwen Yang
May 14, 2020·Stem Cells International·Ronghua YangJulin Xie
Jul 17, 2020·Cancer Reports·Sarita JoshiOle Petter F Clausen
Sep 17, 2020·Reviews in Endocrine & Metabolic Disorders·Giovanni VitaleMaria Chiara Zatelli
Apr 15, 2020·International Journal of Molecular Sciences·Luc RochetteGabriel Malka
Jan 9, 2021·Cell Death & Disease·Xuan WangYunfang Wang
Nov 20, 2020·The Journal of Investigative Dermatology·Qiuming YaoMaryam M Asgari
Oct 19, 2017·Developmental Biology·Margarita M DzamaNatalia Soshnikova
May 11, 2020·Cell Stem Cell·Vivian Fu, Kun-Liang Guan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.