Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells

Seminars in Cell & Developmental Biology
Silvia Muñoz-DescalzoAlfonso Martinez Arias

Abstract

Wnt/ß-catenin signalling is a widespread cell signalling pathway with multiple roles during vertebrate development. In mouse embryonic stem (mES) cells, there is a dual role for ß-catenin: it promotes differentiation when activated as part of the Wnt/ß-catenin signalling pathway, and promotes stable pluripotency independently of signalling. Although mES cells resemble the preimplantation epiblast progenitors, the first requirement for Wnt/ß-catenin signalling during mouse development has been reported at implantation [1,2]. The relationship between ß-catenin and pluripotency and that of mES cells with epiblast progenitors suggests that ß-catenin might have a functional role during preimplantation development. Here we summarize the expression and function of Wnt/ß-catenin signalling elements during the early stages of mouse development and consider the reasons why the requirement in ES cells do not reflect the embryo.

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Citations

Feb 27, 2016·Journal of Cellular Physiology·Bor Luen Tang
Jan 13, 2017·Protoplasma·Tomas Vacik, Ivan Raska
Mar 3, 2020·Genes & Development·Xinlong LuoKian Peng Koh
Oct 17, 2019·Cold Spring Harbor Perspectives in Biology·Melanie D White, Nicolas Plachta
Jul 21, 2020·Cell Research·Kazuhiko MatsuokaErwin F Wagner
Nov 20, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sergio MencheroMiguel Manzanares
Aug 28, 2020·Cancer Management and Research·Ming-Fan YeJing Zhang

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