Wnt signaling, a novel pathway regulating blood pressure? State of the art review

Atherosclerosis
Maen D Abou Ziki, Arya Mani

Abstract

Recent antihypertensive trials show conflicting results on blood pressure (BP) targets in patient populations with different metabolic profiles, with lowest benefit from tight BP control observed in patients with type 2 diabetes mellitus. This paradox could arise from the heterogeneity of study populations and underscores the importance of precision medicine initiatives towards understanding and treating hypertension. Wnt signaling pathways and genetic variations in its signaling peptides have been recently associated with metabolic syndrome, hypertension and diabetes, generating a breakthrough for advancement of precision medicine in the field of hypertension. We performed a review of PubMed for publications addressing the contributions of Wnt to BP regulation and hypertension. In addition, we performed a manual search of the reference lists for relevant articles, and included unpublished observations from our laboratory. There is emerging evidence for Wnt's role in BP regulation and its involvement in the pathogenesis of hypertension. Wnt signaling has pleiotropic effects on distinct pathways that involve vascular smooth muscle plasticity, and cardiac, renal, and neural physiology. Hypertension is a heterogeneous disease with...Continue Reading

Citations

May 24, 2020·Journal of Clinical Laboratory Analysis·Shuying ZhengLina Zhang
Nov 9, 2018·Frontiers in Cardiovascular Medicine·Manna LiJian Xu
Dec 12, 2019·BMC Bioinformatics·Elham Khodayari MoezIrina Dinu
Jun 10, 2018·Current Hypertension Reports·Alexandre ValléeJacques Blacher
Dec 15, 2020·Clinical and Experimental Hypertension : CHE·Zhenbo TaoLina Zhang
Jan 6, 2021·Molecular and Cellular Biochemistry·Ma Eugenia Garay-SevillaArmando Rojas
Jul 7, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Irena KasackaAlicja Lewandowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Current Opinion in Lipidology
Aikaterini TsaousiSarah J George
Journal of the American Society of Hypertension : JASH
Friedrich C Luft
Liver International : Official Journal of the International Association for the Study of the Liver
Shir Lin KohChristopher Christophi
Cardiovascular & Hematological Agents in Medicinal Chemistry
Liam M McCormickDavid P Dutka
Scientific American
Jeneen Interlandi
© 2022 Meta ULC. All rights reserved