Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells

Genes
Megan L RasmussenVivian Gama

Abstract

The core transcriptional network regulating stem cell self-renewal and pluripotency remains an intense area of research. Increasing evidence indicates that modified regulation of basic cellular processes such as mitochondrial dynamics, apoptosis, and cell cycle are also essential for pluripotent stem cell identity and fate decisions. Here, we review evidence for Wnt regulation of pluripotency and self-renewal, and its connections to emerging features of pluripotent stem cells, including (1) increased mitochondrial fragmentation, (2) increased sensitivity to cell death, and (3) shortened cell cycle. We provide a general overview of the stem cell-specific mechanisms involved in the maintenance of these uncharacterized hallmarks of pluripotency and highlight potential links to the Wnt signaling pathway. Given the physiological importance of stem cells and their enormous potential for regenerative medicine, understanding fundamental mechanisms mediating the crosstalk between Wnt, organelle-dynamics, apoptosis, and cell cycle will be crucial to gain insight into the regulation of stemness.

References

Apr 3, 1992·Cell·G I EvanD C Hancock
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Nov 6, 1998·Science·J A ThomsonJ M Jones
Feb 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kui Lei, Roger J Davis
Apr 30, 2003·Nature·Tannishtha ReyaIrving L Weissman
Jul 15, 2003·Molecular Biology of the Cell·David OlmedaAmparo Cano
Sep 13, 2003·Science·Yukiko M YamashitaMargaret T Fuller
Jan 3, 2004·Nature Neuroscience·Stephen C NoctorArnold R Kriegstein
Jun 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael T HemannScott W Lowe
Sep 17, 2004·Nature Reviews. Genetics·Randall T MoonAjamete Kaykas
Nov 19, 2004·Nature·Joan Massagué
Jan 29, 2005·EMBO Reports·Andreas HerbstWilliam P Tansey
Jul 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michel V HadjihannasJürgen Behrens
Sep 15, 2006·Journal of Cellular Physiology·Klaus A BeckerGary S Stein
Jan 24, 2007·Nature Reviews. Neuroscience·H Troy GhashghaeiE S Anton
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Joanna Bloom, Frederick R Cross
May 22, 2007·Nature Reviews. Neuroscience·Colette Dehay, Henry Kennedy
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fang ShuJun Wu
Jun 29, 2007·Nature·I Gabrielle M BronsLudovic Vallier
Jul 25, 2007·The Journal of Cell Biology·Karni SchlessingerAlan Hall

❮ Previous
Next ❯

Citations

Mar 5, 2019·Journal of Periodontal Research·Karim M Fawzy El-SayedChristof E Dörfer
Jul 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Xiulian XiaXiaolan Yu
May 12, 2019·Scientific Reports·Sandra Laner-PlambergerKatharina Schallmoser
Aug 28, 2020·Frontiers in Endocrinology·Yen-Hsiang ChangPei-Wen Wang
Jul 16, 2020·Gastroenterology Report·Yaritza Delgado-DeidaArianne L Theiss
Dec 4, 2020·International Journal of Molecular Sciences·Sara El-Sahli, Lisheng Wang
Apr 4, 2021·International Journal of Molecular Sciences·Yu-Jih SuShao-Wen Weng
Jul 30, 2021·Nature Communications·Tongcheng QianMelissa C Skala

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
GTPase
ubiquitination

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Biochimica Et Biophysica Acta
Kevin Andrew Uy Gonzales, Huck-Hui Ng
Stem Cells and Development
Anaïs WanetPatricia Renard
Human Molecular Genetics
Lingyi Chen, George Q Daley
© 2022 Meta ULC. All rights reserved