Jan 1, 2008

Wnt signaling and skeletal development

Cellular Signalling
Fei LiuCun-Yu Wang


Wnt proteins are a family of secreted proteins that regulate many aspects of cellular functions. The discovery that mutations in low-density lipoprotein receptor-related protein 5, a putative Wnt coreceptor, could positively and negatively affect bone mass in humans generated an enormous amount of interest in the possible role of the Wnt signaling pathway in skeletal biology. Over the last decade, considerable progress has been made in determining the role of the canonical Wnt signaling pathway in various aspects of skeletal development. Furthermore, recent evidence indicates the important role of non-canonical Wnt signaling in skeletal development. In this review we discuss the current understanding of the role of Wnt signaling in chondrogenesis, osteoblastogenesis, and osteoclastogenesis.

  • References32
  • Citations70


Mentioned in this Paper

EP300 protein, human
Biochemical Pathway
Lymphoid enhancer-binding factor 1
Intramembranous Bone Formation
Bone Resorption
AXIN1 gene
TCF7 gene
PRRX1 wt Allele

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