Wnt Signaling and Survival of Women With High-Grade Serous Ovarian Cancer: A Brief Report

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Brandon-Luke L SeagleShohreh Shahabi

Abstract

Ovarian cancer is the gynecologic malignancy with the highest case-fatality rate due to the development of chemotherapy resistance. Predictors of chemotherapy response are needed to guide chemotherapy selection and improve survival for patients with ovarian cancer. Wnt signaling may impact chemoresistance in ovarian cancer. We studied The Cancer Genome Atlas patients with ovarian cancer treated with intraperitoneal or intravenous-only adjuvant chemotherapy. Cox regression tested associations of expression of 26 Wnt pathway genes with progression-free survival and overall survival. Permutation tests compared survival between chemotherapy groups stratified by expression. P values are two-tailed. Increased FZD3 was associated with increased survival (intraperitoneal group, overall survival: hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.11-0.72, P = 0.009; progression-free survival: HR, 0.58; 95% CI, 0.37-0.92, P = 0.020) (intravenous-only group, overall survival: HR, 0.85; 95% CI, 0.72-0.99, P = 0.039; progression-free survival: HR, 0.83; 95% CI, 0.73-0.95, P = 0.006). Low FZD3 predicted decreased overall survival after intraperitoneal versus intravenous-only chemotherapy (21.7 vs 33.3 months, P < 0.0001). Increased APC...Continue Reading

References

Jan 6, 2006·The New England Journal of Medicine·Deborah K ArmstrongUNKNOWN Gynecologic Oncology Group
Oct 13, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel G RosenJinsong Liu

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Citations

Jan 5, 2020·Virchows Archiv : an International Journal of Pathology·Michal ChehoverBen Davidson
Jul 19, 2020·Journal of Cancer Research and Clinical Oncology·Till KaltofenFabian Trillsch

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