Wnt Signaling Cascade in Dendritic Cells and Regulation of Anti-tumor Immunity.

Frontiers in Immunology
Amol SuryawanshiSanthakumar Manicassamy

Abstract

Dendritic cells (DCs) control the strength and quality of antigen-specific adaptive immune responses. This is critical for launching a robust immunity against invading pathogens while maintaining a state of tolerance to self-antigens. However, this also represents a fundamental barrier to anti-tumor immune responses and cancer immunotherapy. DCs in the tumor microenvironment (TME) play a key role in this process. The factors in the TME and signaling networks that program DCs to a regulatory state are not fully understood. Recent advances point to novel mechanisms by which the canonical Wnt signaling cascade in DCs regulates immune suppression, and the same pathway in tumors is associated with the evasion of anti-tumor immunity. Here, we review these recent advances in the context of the pleiotropic effects of the Wnts in shaping anti-tumor immune responses by modulating DC functions. In addition, we will discuss how Wnt/β-catenin pathway in DCs can be targeted for successful cancer immunotherapy.

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Citations

Sep 3, 2020·International Journal of Molecular Sciences·Yongsheng RuanYong-Mi Kim
Apr 7, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manfred B LutzBjörn E Clausen
Jul 22, 2021·Cancer Cell International·Yanming LuoHaiyang Yu
Aug 17, 2021·Frontiers in Immunology·Indumathi ManoharanSanthakumar Manicassamy
Aug 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Indumathi ManoharanSanthakumar Manicassamy

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