Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans

Developmental Biology
Haiyan Ren, Hong Zhang

Abstract

The Wnt signaling pathway regulates multiple aspects of the development of stem cell-like epithelial seam cells in Caenorhabditis elegans, including cell fate specification and symmetric/asymmetric division. In this study, we demonstrate that lit-1, encoding the Nemo-like kinase in the Wnt/beta-catenin asymmetry pathway, plays a role in specifying temporal identities of seam cells. Loss of function of lit-1 suppresses defects in retarded heterochronic mutants and enhances defects in precocious heterochronic mutants. Overexpressing lit-1 causes heterochronic defects opposite to those in lit-1(lf) mutants. LIT-1 exhibits a periodic expression pattern in seam cells within each larval stage. The kinase activity of LIT-1 is essential for its role in the heterochronic pathway. lit-1 specifies the temporal fate of seam cells likely by modulating miRNA-mediated silencing of target heterochronic genes. We further show that loss of function of other components of Wnt signaling, including mom-4, wrm-1, apr-1, and pop-1, also causes heterochronic defects in sensitized genetic backgrounds. Our study reveals a novel function of Wnt signaling in controlling the timing of seam cell development in C. elegans.

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Citations

Jul 8, 2014·PloS One·Melissa LaBontyErin J Cram
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Renee M Miller, Douglas S Portman
Oct 11, 2011·Nature Structural & Molecular Biology·Antony M JoseCraig P Hunter
Oct 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Xiaochang ZhangMin Han
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Omid F Harandi, Victor R Ambros
Sep 11, 2012·Cell Metabolism·Marcelo A MoriC Ronald Kahn
Jan 9, 2015·PLoS Genetics·Tomoko UeharaShohei Mitani
Jul 17, 2019·BMC Developmental Biology·Avijit MallickBhagwati P Gupta
Feb 28, 2016·G3 : Genes - Genomes - Genetics·Zhiji RenVictor Ambros
Apr 10, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Wei LiangJie Hu
Mar 25, 2021·Nucleic Acids Research·Vinay K MayyaThomas F Duchaine
May 15, 2021·Genes and Immunity·Dilawar Ahmad MirKrishnaswamy Balamurugan
Oct 1, 2021·Cell Division·Shaan N Chhabra, Brian W Booth
Jul 18, 2014·Genes & Development·Wen-Hui Lien, Elaine Fuchs

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