Wnt signaling: implications in endoderm development and pancreas organogenesis

Current Opinion in Cell Biology
Katharina ScheibnerHeiko Lickert

Abstract

The pancreas is derived from the foregut endoderm during embryonic development. After gastrulation and endoderm germ layer formation complex morphogenetic events coupled with cell differentiation programs pattern the gut tube and induce pancreas organogenesis. This results in formation of exocrine, ductal and hormone-producing endocrine cells. Among these, endocrine cells are responsible for blood glucose homeostasis and their malfunction leads to diabetes mellitus, which cannot be stopped or reversed by the current standard treatments. Thus, intense efforts to regenerate or replace the lost or dysfunctional insulin-producing β-cells are on the way. This depends on identifying the factors that coordinate pancreas organogenesis. Here, we highlight the contribution of canonical and non-canonical Wnt signaling branches in orchestrating endoderm formation, pancreatic morphogenesis as well as endocrine cell formation and function.

Citations

Nov 2, 2019·International Journal of Molecular Sciences·Ciro SalinnoMostafa Bakhti
Mar 3, 2020·Frontiers in Veterinary Science·Suryo KuncorojaktiChenphop Sawangmake
Oct 15, 2020·Reviews in Endocrine & Metabolic Disorders·Rout George KerrySabuj Sahoo
Mar 1, 2021·Life Sciences·Arnab SarkarTapan Kumar Maity
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Yuting FuSiqin Bao
Jun 4, 2021·Frontiers in Cell and Developmental Biology·Yifan WuPei Wang

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