Wnt Signaling in Normal and Malignant Stem Cells

Current Stem Cell Reports
Dheeraj Bhavanasi, Peter S Klein

Abstract

Wnt signaling plays important roles in stem cell self-renewal and differentiation in adults as well as in embryonic development. Mutations that activate canonical Wnt/β-catenin signaling also initiate and maintain several cancer states, including colorectal cancer and leukemia, and hence Wnt inhibitors are currently being explored as therapeutic options. In this review, we summarize previous studies and update recent findings on canonical Wnt signaling and its components, as well as their roles in somatic stem cell homeostasis and maintenance of cancer initiating cells.

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Citations

Jan 3, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yu UsamiMotomi Enomoto-Iwamoto
Feb 6, 2019·Cancers·Randall J Ruch
Mar 15, 2019·Journal of Experimental & Clinical Cancer Research : CR·Hiroshi FukamachiShinji Tanaka
Oct 28, 2019·Anti-cancer Agents in Medicinal Chemistry·Xylia Q PetersMahmoud E S Soliman
Apr 21, 2020·Frontiers in Physiology·Asmat Ullah KhanJingxing Dai
Jan 9, 2021·Journal of Cellular and Molecular Medicine·Yifeng DaiTiansheng Zeng
Nov 20, 2020·Stem Cell Research & Therapy·Fiorella RossiKarl-Henrik Grinnemo

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