Wnt signaling induces vulva development in the nematode Pristionchus pacificus

Current Biology : CB
Huiyu TianR J Sommer

Abstract

The Caenorhabditis elegans vulva is induced by a member of the epidermal growth factor (EGF) family that is expressed in the gonadal anchor cell, representing a prime example of signaling processes in animal development. Comparative studies indicated that vulva induction has changed rapidly during evolution. However, nothing was known about the molecular mechanisms underlying these differences. By analyzing deletion mutants in five Wnt pathway genes, we show that Wnt signaling induces vulva formation in Pristionchus pacificus. A Ppa-bar-1/beta-catenin deletion is completely vulvaless. Several Wnt ligands and receptors act redundantly in vulva induction, and Ppa-egl-20/Wnt; Ppa-mom-2/Wnt; Ppa-lin-18/Ryk triple mutants are strongly vulvaless. Wnt ligands are differentially expressed in the somatic gonad, the anchor cell, and the posterior body region, respectively. In contrast, previous studies indicated that Ppa-lin-17, one of the Frizzled-type receptors, has a negative role in vulva formation. We found that mutations in Ppa-bar-1 and Ppa-egl-20 suppress the phenotype of Ppa-lin-17. Thus, an unexpected complexity of Wnt signaling is involved in vulva induction and vulva repression in P. pacificus. This study provides the first m...Continue Reading

References

Jul 23, 1999·Development Genes and Evolution·C B Sigrist, R J Sommer
May 16, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ray L Hong, Ralf J Sommer
Jul 25, 2006·Current Biology : CB·Benjamin SchlagerRalf J Sommer
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Andre Pires da Silva
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Ralf J Sommer
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Paul W Sternberg
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Min-Ho Lee, Tim Schedl

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Citations

Jul 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·David RudelRalf J Sommer
Mar 4, 2011·Molecular Biology and Evolution·Ruxandra I MolnarRalf J Sommer
Apr 21, 2012·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·A Pires-daSilva, M Parihar
Aug 3, 2013·WormBook : the Online Review of C. Elegans Biology·Meera V Sundaram
Jul 5, 2011·Annual Review of Genetics·Ralf J Sommer, Adrian Streit
Feb 14, 2012·Trends in Genetics : TIG·Marie-Anne Félix, Michalis Barkoulas
Mar 21, 2009·Genesis : the Journal of Genetics and Development·Benjamin SchlagerRalf J Sommer
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Ralf J Sommer, Daniel J Bumbarger
Nov 14, 2015·Annual Review of Cell and Developmental Biology·Ralf J Sommer, Melanie G Mayer
Oct 1, 2011·Current Biology : CB·Ralf J Sommer, Akira Ogawa
Jul 19, 2011·Developmental Cell·Beth A RowanDaniel Koenig
Jan 22, 2009·Developmental Biology·Hui YuPaul W Sternberg
Apr 18, 2013·Nature Communications·Simone Kienle, Ralf J Sommer
Jun 7, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ralf J Sommer
Apr 17, 2009·Nature Reviews. Genetics·Ralf J Sommer
Aug 9, 2012·Physical Biology·Marie-Anne Félix
Jan 22, 2020·Molecular Biology and Evolution·Helen M ChamberlinBhagwati P Gupta
Jan 29, 2021·Journal of Theoretical Biology·Carly WilliamsonAdriana T Dawes
Apr 24, 2021·G3 : Genes - Genomes - Genetics·Charles Nelson, Victor Ambros

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