Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors

Acta Pharmacologica Sinica
Wen-Bin FuChun-Yu Zeng

Abstract

Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical and economic burdens worldwide. Wnt signaling pathways play an important role in developmental processes such as tissue patterning, cell differentiation and cell division. Appropriate regulation of the activities of Wnt signaling pathways is also important for heart development and healing in post-MI heart. Moreover, Wnt pathway inhibitors have been identified as novel antitumor drugs and applied in ongoing clinical trials. This research progress has generated increasing interests for investigating the effects of Wnt pathway inhibitors on MI healing. In this short review, we summarize the roles of Wnt signaling pathways in post-MI heart and the therapeutic effects of Wnt pathway inhibitors on MI, and discuss the underlying mechanisms of Wnt pathway inhibitors in cardiac repairing.

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Citations

Nov 27, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Qiang XueXuefeng Guang
Mar 8, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Karmani ShahBhumika Patel
Apr 13, 2021·Frontiers in Cardiovascular Medicine·Siyuan ZhaoYan Kang
Nov 16, 2020·The Annals of Thoracic Surgery·Michael J JarrettDavid A Fullerton
Aug 8, 2021·Cells·Hitoshi Kurose

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Methods Mentioned

BETA
nuclear translocation
transfection

Clinical Trials Mentioned

NCT02675946

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