Wnt Signaling-Related Osteokines and Transforming Growth Factors Before and After a Single Bout of Plyometric Exercise in Child and Adolescent Females

Pediatric Exercise Science
Jennifer DekkerP Klentrou

Abstract

This study examined resting levels of catabolic and anabolic osteokines related to Wnt signaling and their responses to a single bout of plyometric exercise in child and adolescent females. Fourteen premenarcheal girls [10.5 (1.8) y old] and 12 postmenarcheal adolescent girls [15.0 (1.0) y old] performed a plyometric exercise trial. One resting and 3 postexercise blood samples (5 min, 1 h, and 24 h postexercise) were analyzed for sclerostin, dickkopf-1 (DKK-1), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-β ligand (RANKL), and transforming growth factors (TGF-β1, TGF-β2, and TGF-β3). Premenarcheal girls had significantly higher resting sclerostin, TGF-β1, TGF-β2, and TGF-β3 than the postmenarcheal girls, with no significant time effect or group-by-time interaction. DKK-1 was higher in premenarcheal compared with postmenarcheal girls. There was an overall significant DKK-1 decrease from baseline to 1 h postexercise, which remained lower than baseline 24 h postexercise in both groups. There was neither a significant group effect nor group-by-time interaction in OPG, RANKL, and their ratio. RANKL decreased 5 min postexercise compared with baseline and remained significantly lower from baseline 24 h following t...Continue Reading

References

Jan 1, 1993·Medicine and Science in Sports and Exercise·J F SallisJ A Nelson
Oct 13, 2001·The Journal of Pediatrics·K J MackelvieP R Crocker
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Oct 12, 2004·Gene·Jennifer J WestendorfTania M Schroeder
Oct 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark L JohnsonWim Van Hul
May 4, 2006·The Journal of Clinical Investigation·Venkatesh KrishnanOrmond A Macdougald
Aug 16, 2006·The Journal of Biological Chemistry·John A RobinsonFrederick J Bex
Dec 20, 2007·The Journal of Biological Chemistry·Alexander G RoblingCharles H Turner
Apr 30, 2008·Journal of the American Dietetic Association·Karen Weber CullenIssa Zakeri
Aug 9, 2008·Blood·Joseph J PinzoneJohn D Shaughnessy
Feb 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Faryal S MirzaJoseph A Lorenzo
May 26, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·James R EdwardsGregory R Mundy
Jul 17, 2010·Sports Medicine·Giuseppe BanfiGiuseppe Lippi
May 28, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S KirmaniS Khosla
Dec 14, 2011·Bone·Gabriela G LootsDamian C Genetos
Apr 13, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P K FazeliM Misra
Apr 2, 2014·Calcified Tissue International·Giorgio RadettiDavide Gatti
May 13, 2014·Maturitas·Stavros C Manolagas
Jul 18, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R Sapir-Koren, G Livshits
Aug 27, 2014·Biomaterials·Ugo RipamontiCarlo Ferretti
Nov 7, 2014·Medicine and Science in Sports and Exercise·Yasmeen A MezilPanagiota Klentrou
Jan 19, 2015·Endocrine·Stefano MoraGian Vincenzo Zuccotti
May 29, 2015·European Journal of Applied Physiology·Kimberly KishBareket Falk
Sep 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B FalkS Radom-Aizik
Feb 26, 2016·Current Osteoporosis Reports·Robert L Jilka, Charles A O'Brien

❮ Previous
Next ❯

Citations

Oct 12, 2017·Pediatric Exercise Science·Geraldine NaughtonAdam Baxter-Jones
Apr 16, 2020·Journal of the International Society of Sports Nutrition·Alexandros TheocharidisPanagiota Klentrou
Jun 6, 2020·Current Osteoporosis Reports·Stephen M CornishDarren G Candow
Oct 25, 2017·Calcified Tissue International·Bareket Falk, Panagiota Klentrou
Mar 10, 2020·BioMed Research International·Mohammad TobeihaSadegh Jafarnejad
May 31, 2018·Physiological Reports·Katelyn I GuerriereRonald W Matheny
Dec 14, 2019·Journal of Bone Metabolism·Seok-Ki MinChang-Sun Kim
Nov 5, 2020·BioMed Research International·Katlynne NelsonPanagiota Klentrou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.