Wnt signaling went derailed again: a new track via the LIN-18 receptor?

Cell
Xi He

Abstract

In this issue of Cell, Inoue et al. (2004) reports that LIN-18, an atypical receptor tyrosine kinase related to mammalian Ryk and Drosophila Derailed, mediates Wnt signaling in parallel to LIN-17/Frizzled (Fz) during worm vulval development. LIN-18/Ryk and LIN-17/Fz appear to exhibit distinct Wnt specificity, and surprisingly, the LIN-18 intracellular domain may be dispensable.

Citations

Jul 14, 2007·Cancer Science·Yoshimi Endo, Jeffrey S Rubin
Jan 11, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ravneet Kaur KhanguraAmteshwar Singh Jaggi
Jun 24, 2006·Development·Xi He, Jeffrey D Axelrod

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