Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegans

Developmental Cell
Massimo Hilliard, C I Bargmann

Abstract

Secreted proteins of the Wnt family affect axon guidance, asymmetric cell division, and cell fate. We show here that C. elegans Wnts acting through Frizzled receptors can shape axon and dendrite trajectories by reversing the anterior-posterior polarity of neurons. In lin-44/Wnt and lin-17/Frizzled mutants, the polarity of the PLM mechanosensory neuron is reversed along the body axis: the long PLM process, PLM growth cone, and synapses are posterior to its cell body instead of anterior. Similarly, the polarity of the ALM mechanosensory neuron is reversed in cwn-1 egl-20 Wnt double mutants, suggesting that different Wnt signals regulate neuronal polarity at different anterior-posterior positions. LIN-17 protein is asymmetrically localized to the posterior process of PLM in a lin-44-dependent manner, indicating that Wnt signaling redistributes LIN-17 in PLM. In this context, Wnts appear to function not as instructive growth cone attractants or repellents, but as organizers of neuronal polarity.

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Citations

Jun 15, 2007·Nature Cell Biology·Xian ZhangZhen-Ge Luo
Dec 12, 2012·Molecular Biology of the Cell·Leonie KirszenblatMassimo A Hilliard
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Sabina Tahirovic, Frank Bradke
May 11, 2010·Cold Spring Harbor Perspectives in Biology·F Polleux, William Snider
Jun 11, 2010·Cold Spring Harbor Perspectives in Biology·Barry J Dickson, Yimin Zou
Sep 17, 2008·Genes & Development·Yong-Jin ChoiXi He
Mar 23, 2013·Science·Shukry J HabibRoel Nusse
Apr 7, 2010·Annual Review of Neuroscience·Kang Shen, Peter Scheiffele
Apr 30, 2009·Annual Review of Neuroscience·Anthony P Barnes, Franck Polleux
Jun 19, 2008·Annual Review of Neuroscience·Patricia C Salinas, Yimin Zou
Oct 13, 2006·PLoS Biology·Mohammed SrahnaBassem A Hassan
Sep 29, 2011·PLoS Biology·Leonie KirszenblatMassimo A Hilliard
Sep 14, 2011·PLoS Genetics·Leticia Sanchez-AlvarezAntonio Colavita
Sep 21, 2013·G3 : Genes - Genomes - Genetics·Osama RefaiJeb Gaudet
Jun 22, 2012·Annual Review of Neuroscience·Pei-lin Cheng, Mu-ming Poo
Aug 12, 2014·Experimental Cell Research·Giovanna Lalli
Apr 14, 2016·Worm·Naomi Levy-Strumpf
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Chaogu ZhengMartin Chalfie
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May 11, 2011·Developmental Neurobiology·Guo-Ying Yang, Zhen-Ge Luo
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