Wnt signals can function as positional cues in establishing cell polarity

Developmental Cell
Bob GoldsteinHitoshi Sawa

Abstract

Wnt signaling plays important roles in cell polarization in diverse organisms, and loss of cell polarity is an early event in tumorigenesis caused by mutations in Wnt pathway genes. Despite this, the precise roles of Wnt proteins in cell polarization have remained elusive. In no organism has it been shown that the asymmetric position of a Wnt signal is essential to establishing a cell's polarity. Attempts to test this by ubiquitous expression of Wnt genes have suggested that Wnt signals might act only as permissive factors in cell polarization. Here we find, by using cell manipulations and ectopic gene expression in C. elegans, that the position from which Wnt signals are presented can determine the polarity of both embryonic and postembryonic cells. Furthermore, the position from which a Wnt signal is presented can determine the polarity of Frizzled receptor localization, suggesting that the polarizing effect of Wnt is likely to be direct. These results demonstrate that Wnt proteins can function as positional cues in establishing cell polarity.

References

May 1, 1974·Genetics·S Brenner
Feb 11, 1994·Science·M ChalfieD C Prasher
Jan 1, 1995·Methods in Cell Biology·L G Edgar
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·L Bloom, H R Horvitz
Feb 7, 1998·Genes & Development·K M Cadigan, R Nusse
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·A Martinez Arias
May 23, 2002·Developmental Cell·Paul N Adler
Jun 1, 2002·Science·Randall T MoonNorbert Perrimon
Jul 26, 2002·Seminars in Cell & Developmental Biology·Michael A Herman
Nov 15, 2002·Developmental Cell·Jean-Paul Vincent, Laurence Dubois
Nov 26, 2002·Nature Cell Biology·Julia A KaltschmidtAlfonso Martinez Arias
Mar 28, 2003·Nature·Shingo YoshikawaJohn B Thomas
Jun 14, 2003·TheScientificWorldJournal·Jeffrey D Axelrod, Helen McNeill
Sep 12, 2003·Developmental Cell·Michael T VeemanRandall T Moon
Dec 13, 2003·Science·Anna I LyuksyutovaYimin Zou
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Elena SanchoHans Clevers
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Aug 4, 2005·Genes & Development·Kuniaki NakamuraCraig C Mello
Sep 6, 2005·Nature Genetics·Emmanuel Caussinus, Cayetano Gonzalez

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Citations

Jun 8, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Calli E MerkelThomas J Carroll
Jun 23, 2009·Nature Genetics·Courtney M KarnerThomas J Carroll
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Soyoung KimMasaki Shirayama
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Eszter K VladarJeffrey D Axelrod
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Edwin Munro, Bruce Bowerman
Jul 20, 2007·Genes & Development·Kenta HaraTatsuo Kakimoto
Mar 23, 2013·Science·Shukry J HabibRoel Nusse
Jun 19, 2008·Annual Review of Neuroscience·Patricia C Salinas, Yimin Zou
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bryan T PhillipsJudith Kimble
Dec 3, 2014·Experimental Cell Research·Ulrike Schnell, Thomas J Carroll
Jul 5, 2011·Journal of Theoretical Biology·Maria-Grazia AscenziGeorge Mohler
Aug 3, 2011·Seminars in Cell & Developmental Biology·Adam D Werts, Bob Goldstein
Jun 24, 2010·Current Opinion in Genetics & Development·Jay D KormishJames D McGhee
Aug 12, 2009·Seminars in Cell & Developmental Biology·Ana M MateusAlfonso Martinez Arias
May 19, 2009·Seminars in Cell & Developmental Biology·Marion Segalen, Yohanns Bellaïche
Dec 19, 2008·Trends in Cell Biology·Aakanksha Singhvi, Gian Garriga
Mar 10, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Vincent Bertrand
Dec 17, 2009·Cell·Christian P Petersen, Peter W Reddien
Oct 9, 2007·Trends in Cell Biology·Kota Mizumoto, Hitoshi Sawa
Jul 24, 2007·Current Opinion in Genetics & Development·Marie Silhankova, Hendrik C Korswagen
Mar 30, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Andrew D Chisholm, Tiffany I Hsiao
Jan 9, 2013·Molecular Systems Biology·Rui Zhen TanAlexander van Oudenaarden
Oct 27, 2011·Organogenesis·Thomas J Carroll, Amrita Das
Feb 27, 2016·Genesis : the Journal of Genetics and Development·Amanda L Zacharias, John Isaac Murray

❮ Previous
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