WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma

Carcinogenesis
Apple LongA K Rustgi

Abstract

Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We have performed laser capture microdissection with RNA microarray analysis on the invasive and non-invasive tumor cells of p53(R175H)-overexpressing OTC samples to determine candidate genes facilitating tumor invasion. WNT10A was found to be >4-fold upregulated in the invasive front. Since WNT10A is also prominently upregulated during placode promotion in hair follicle development, a process that requires epithelial cells to thicken and elongate, in order to allow downward growth, we hypothesized that WNT10A may be important in mediating a similar mechanism of tumor cell invasion in ESCC. We have found that WNT10A expression is significantly upregulated in human ESCC, when compared with normal adjacent tissue. Furthermore, high WNT10A expression levels correlate with poor survival. Interestingly, we observe that WNT10A is expressed early in embryogenesis, but is reduced dramatically postnatally. We demonstrate that overexpression of WNT10a promotes migration and invasion, and prolifer...Continue Reading

References

Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·T NishihiraT Kuroki
Aug 15, 1995·Cancer·H NakagawaA K Rustgi
Jul 1, 1997·Emerging Infectious Diseases·S F AltekruseD L Swerdlow
Feb 23, 1999·The American Journal of Pathology·V J WielengaS T Pals
Mar 30, 2001·The Journal of Biological Chemistry·J LiK B Marcu
May 15, 2001·Biochemical and Biophysical Research Communications·H KirikoshiM Katoh
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Apr 30, 2003·Nature·Tannishtha ReyaIrving L Weissman
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Dec 19, 2003·Nucleic Acids Research·Axel ViselGregor Eichele
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Han TangLorraine J Gudas
Mar 25, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tomohiro NaritaTsutomu Nohno
Oct 4, 2006·Genes & Development·Tadashi OkuboBrigid L M Hogan
Jul 12, 2008·Nature Reviews. Immunology·Frank J T StaalMachteld M Tiemessen
Apr 24, 2009·Developmental Cell·Nan GaoKlaus H Kaestner
May 28, 2009·European Journal of Human Genetics : EJHG·Sadia NawazNiklas Dahl
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Mar 23, 2012·Cold Spring Harbor Perspectives in Biology·Paul Polakis
Jun 12, 2012·Cell·Hans Clevers, Roel Nusse
Jul 13, 2012·Differentiation; Research in Biological Diversity·Rani NajdiMarian L Waterman
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Karl Willert, Roel Nusse
Jan 26, 2013·Current Opinion in Cell Biology·Jane D HollandWalter Birchmeier
Dec 18, 2013·Bioinformatics·Andreas KrämerStuart Tugendreich
Apr 10, 2014·American Journal of Medical Genetics. Part a·Peter H Itin

❮ Previous
Next ❯

Citations

Jun 9, 2016·Oncogene·F LinkeD Kube
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hirohisa OkabeKari Nichole Nejak-Bowen
Nov 8, 2016·Gastroenterology Research and Practice·Peng SuZiqiang Tian
Aug 31, 2016·Cancer Science·Hiroaki TaniguchiKohzoh Imai
Jul 15, 2016·Scientific Reports·Asoke K TalukderPatrice P Denèfle
Jun 20, 2018·Annals of the New York Academy of Sciences·Fazlur Rahman TalukdarZdenko Herceg
Mar 29, 2019·Journal of Cellular and Molecular Medicine·Lei DaiHongxin Deng
Dec 10, 2015·International Journal of Oncology·Yu-Feng XiaoShi-Ming Yang
Jul 6, 2017·Oncology Reports·Tianyi DongShili Liu
Nov 23, 2017·Oncology Letters·Ping LiChangxiu Wang
Nov 25, 2016·BMC Medical Genetics·Birgitta BergendalNiklas Dahl
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Nattawan SuwannakulMariko Murata
Dec 19, 2019·Cellular Oncology (Dordrecht)·Ali Fatehi HassanabadJacques Raphael
Apr 9, 2017·Journal of Gastroenterology·Atsushi ShiozakiEigo Otsuji
Jan 1, 2021·Histopathology·Matthew W Rosenbaum, Raul S Gonzalez
Mar 6, 2021·Frontiers in Oncology·Plabon Kumar DasAlfred K Lam
Oct 2, 2021·International Journal of Oral Science·Mengqi ZhouJan C-C Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.