Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells

Medical Oncology
Yong XuJihui Hao

Abstract

This study aimed to investigate the expression of Wnt2 protein in pancreatic cancer tissues and pancreatic stellate cells (PSCs), and determine its effect on the biological functions of pancreatic cancer cells. Immunohistochemistry was used to study the expression pattern of Wnt2 in pancreatic cancer tissues. The relationship between Wnt2 protein expression level and patient prognosis was analyzed. PSCs were isolated and cultured. The expression of Wnt2 in activated PSCs was investigated using Western blot and immunofluorescence. We also analyzed the effect of Wnt2 recombinant protein and stellate cell culture supernatant on the Wnt/β-catenin signaling pathway, as well as the effect of Wnt2 recombinant protein on the biological functions of pancreatic cancer cells. The expression of Wnt2 in interstitial cells of pancreatic cancer was correlated with the prognosis of pancreatic cancer. Wnt2 protein was expressed in activated PSCs. Both stellate cell culture supernatant and Wnt2 recombinant protein could activate the classic Wnt/β-catenin signaling pathway. Wnt2 protein enhanced the migration, invasion, and metastasis of pancreatic cancer cells. These results suggested that Wnt2 protein secreted by PSCs promoted the progression o...Continue Reading

References

Jan 16, 2007·BMC Developmental Biology·James M WellsAndrew M Lowy
Feb 5, 2008·Cancer Research·Rosa F HwangCraig D Logsdon
Apr 3, 2008·Cancer Research·Alain VonlaufenMinoti V Apte
Feb 26, 2009·Neoplasma·J K ParkW S Park
May 5, 2009·Neoplasia : an International Journal for Oncology Research·Mert ErkanJörg Kleeff
Sep 4, 2010·Nature Reviews. Cancer·John P MorrisMatthias Hebrok
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Dec 23, 2011·The Biochemical Journal·Mario A ShieldsHidayatullah G Munshi
Jun 14, 2013·Cancer Research·Yaqing ZhangMarina Pasca di Magliano

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Citations

Oct 4, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shuo Qie, J Alan Diehl
Jun 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yichong WangMing Liu
Mar 10, 2017·Scandinavian Journal of Gastroenterology·Daniel AnsariRoland Andersson
Oct 26, 2018·The Korean Journal of Internal Medicine·Jin Niang NanMyung Ah Lee
Feb 18, 2017·World Journal of Gastroenterology : WJG·Ratnakar R BynigeriRupjyoti Talukdar
May 18, 2021·Frontiers in Cell and Developmental Biology·Kristina Y Aguilera, David W Dawson
Aug 31, 2021·Signal Transduction and Targeted Therapy·Fanyuan YuLing Ye

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