Wnt5a-induced cell migration is associated with the aggressiveness of estrogen receptor-positive breast cancer

Oncotarget
Yoshie KobayashiMorihito Okada

Abstract

Elevated expression of Wnt5a is associated with malignancy, cell invasion, and metastasis. The role of Wnt5a expression in breast cancer remains elusive. We investigated the significance of Wnt5a expression in breast cancer. The relationship between Wnt5a expression and clinicopathologic factors was assessed in invasive breast cancer (n = 178) resected at Hiroshima University Hospital between January 2011 and February 2014. Wnt5a was expressed in 69 of 178 cases (39%) of invasive breast cancer and correlated strongly with estrogen receptor (ER) expression (P < 0.001). Wnt5a expression in ER-positive breast cancer correlated significantly with lymph node metastasis, nuclear grade, and lymphatic invasion. The recurrence-free survival was shorter in breast cancer patients with Wnt5a expression than in those without (P = 0.024). The migratory capacity of ER-positive breast cancer cells increased with constitutive expression of Wnt5a and decreased with Wnt5a knockdown. DNA microarray analysis identified activated leukocyte cell adhesion molecule (ALCAM) as the primary gene induced by Wnt5a. ALCAM was expressed in 69% of Wnt5a-positive but only 27% of Wnt5a-negative cancers (κ = 0.444; P < 0.001). The inhibition of ALCAM reversed the...Continue Reading

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Citations

May 22, 2020·Cancer Metastasis Reviews·Pablo Lopez-Bergami, Gastón Barbero
Oct 22, 2020·International Journal of Molecular Sciences·Malvina KoniMaria Felice Brizzi
Aug 11, 2018·Endocrine-related Cancer·Amy CoopesCaroline Elizabeth Ford
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May 29, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ai AmiokaMorihito Okada

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