Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons.

Journal of Neurochemistry
Daniela VallejoNibaldo C Inestrosa

Abstract

Dendritic spines are small, actin-rich protrusions that act as the receiving sites of most excitatory inputs in the central nervous system. The remodeling of the synapse architecture is mediated by actin cytoskeleton dynamics, a process precisely regulated by the small Rho GTPase family. Wnt ligands exert their presynaptic and postsynaptic effects during formation and consolidation of the synaptic structure. Specifically, Wnt5a has been identified as an indispensable synaptogenic factor for the regulation and organization of the postsynaptic side; however, the molecular mechanisms through which Wnt5a induces morphological changes resulting from actin cytoskeleton dynamics within dendritic spines remain unclear. In this work, we employ primary rat hippocampal cultures and HT22 murine hippocampal neuronal cell models, molecular and pharmacological tools, and fluorescence microscopy (laser confocal and epifluorescence) to define the Wnt5a-induced molecular signaling involved in postsynaptic remodeling mediated via the regulation of the small Rho GTPase family. We report that Wnt5a differentially regulates the phosphorylation of Cofilin in neurons through both Ras-related C3 botulinum toxin substrate 1 and cell division cycle 42 de...Continue Reading

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O ThastrupA P Dawson
Mar 23, 1987·FEBS Letters·M CouéE D Korn
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A MatusK Fujiwara
Feb 19, 1993·Neuroscience Letters·J M Dubinsky
Mar 29, 2000·The Journal of Biological Chemistry·M C SubausteK M Hahn
Jun 20, 2000·Trends in Genetics : TIG·M KühlR T Moon
Mar 22, 2001·Nature Reviews. Neuroscience·L Luo
Oct 22, 2002·Nature Neuroscience·Fumitoshi Irie, Yu Yamaguchi
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Jul 30, 2003·Methods in Cell Biology·Peter J Meberg, Matthew W Miller
Sep 30, 2003·Reviews in the Neurosciences·Yanghong MengZhengping Jia
May 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuan GaoYi Zheng
Jul 6, 2004·Molecular and Cellular Neurosciences·Ayumu Tashiro, Rafael Yuste
Sep 14, 2004·Science·Perihan NalbantKlaus M Hahn
Dec 21, 2004·Nature Neuroscience·Silvana B RossoPatricia C Salinas
Jan 27, 2005·The Journal of Biological Chemistry·Yan WangKensaku Mizuno
Apr 9, 2005·Journal of Microscopy·J C Fiala
Jul 26, 2005·Experimental Neurology·Alexander TonkikhPeter L Carlen
Dec 20, 2005·Current Opinion in Neurobiology·Tomoko Tada, Morgan Sheng
Jun 24, 2006·The Journal of Biological Chemistry·Michael D Gordon, Roel Nusse
Apr 5, 2007·Nature Protocols·Stefanie Kaech, Gary Banker
Jun 19, 2008·Annual Review of Neuroscience·Patricia C Salinas, Yimin Zou
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew M TanBryan C Hains
Apr 1, 2009·The Journal of Biological Chemistry·Ginny G FaríasNibaldo C Inestrosa
Apr 22, 2009·The Journal of Cell Biology·Pirta HotulainenPekka Lappalainen
Sep 9, 2009·Development·Renée van Amerongen, Roel Nusse
Feb 6, 2010·Trends in Cell Biology·Barbara W Bernstein, James R Bamburg
Mar 3, 2010·Annual Review of Biophysics·Beáta Bugyi, Marie-France Carlier
May 21, 2010·Biophysical Journal·Hongxia ZhaoPekka Lappalainen
Aug 20, 2010·Molecular Biology of the Cell·Carolina Montenegro-VenegasChristian Gonzalez-Billault
Nov 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lorena Varela-NallarNibaldo C Inestrosa
Dec 22, 2010·F1000 Biology Reports·James R Bamburg, Barbara W Bernstein
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lorenza CianiPatricia C Salinas
Jun 15, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Dale A FortinThomas R Soderling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.