Abstract
Although metal-metal oxide nanoparticles have attracted considerable interest as catalysts, they have attracted little interest in nanomedicine. This is likely due to the fact that metal oxide semiconductors generally require biologically harmful ultraviolet excitation. In contrast, this study focuses upon WO3/Pt nanoparticles, which can be excited by visible light. To optimize the nanoparticles' catalytic performance, platinization was performed at alkaline pH. These nanoparticles destroyed organic dyes, consumed dissolved oxygen and produced hydroxyl radicals. 4T1 breast cancer cells internalized WO3/Pt nanoparticles within the membrane-bound endo-lysosomal compartment as shown by electron and fluorescence microscopy. During visible light exposure, but not in darkness, WO3/Pt nanoparticles manufacture reactive oxygen species, promote lipid peroxidation, and trigger lysosomal membrane disruption. As cells of the immune system degrade organic molecules, produce reactive oxygen species, and activate the lipid peroxidation pathway within target cells, these nanoparticles mimic the chemical attributes of immune effector cells. These biomimetic nanoparticles should become useful in managing certain cancers, especially ocular cancer.
References
Apr 22, 1992·International Journal of Cancer. Journal International Du Cancer·H SaitoM Tsuchiya
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J H Doroshow
Jan 1, 1994·International Journal of Radiation Biology·P A Riley
Jun 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B Safiejko-Mroczka, P B Bell
May 21, 2003·The Journal of Experimental Medicine·Patricia BoyaGuido Kroemer
May 14, 2005·Respiratory Medicine·Dariusz Nowak, Małgorzata Janczak
Sep 14, 2006·Optics Letters·Arnold VainrubVitaly Vodyanoy
Jul 5, 2007·Molecular Interventions·Yumin ChenDaret K St Clair
Sep 13, 2007·Nature Reviews. Molecular Cell Biology·Benoît D'Autréaux, Michel B Toledano
Jun 3, 2008·Journal of the American Chemical Society·Ryu AbeBunsho Ohtani
Aug 12, 2008·BMC Cancer·Kai TaoG Gary Sahagian
Oct 29, 2008·Oncogene·P Boya, G Kroemer
May 2, 2009·Particle and Fibre Toxicology·Sophie LanonePeter Hoet
Jul 17, 2009·Journal of the Royal Society, Interface·Richard OrtegaAsunción Carmona
Apr 3, 2010·Translational Oncology·Thomas H FosterSoumya Mitra
Aug 12, 2010·Environmental Science & Technology·Jungwon KimWonyong Choi
Dec 24, 2010·Photodermatology, Photoimmunology & Photomedicine·Eleni SotiriouDemetris Ioannides
Aug 25, 2011·Chemical Reviews·Huiyong YinNed A Porter
Dec 14, 2011·Journal of Applied Toxicology : JAT·Go HasegawaYoko Ishihara
Feb 18, 2012·Annual Review of Physiology·Joseph A Mindell
Mar 22, 2012·The Journal of Biological Chemistry·Calivarathan LatchoumycandaneThomas M McIntyre
Nov 24, 2012·Cancer Letters·Ran-Ju KimJeong-Seok Nam
Sep 12, 2013·Redox Biology·Corinne M Spickett
Jan 1, 2014·Plastic and Reconstructive Surgery·Justin R HubenakSteven J Kronowitz
May 3, 2014·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Andrea ClarkHoward R Petty
Aug 8, 2014·Metallomics : Integrated Biometal Science·Giuseppe D CiccotostoRoberto Cappai
Citations
Jun 28, 2016·Nanomedicine·Howard R Petty
Mar 23, 2017·ACS Applied Materials & Interfaces·Anqi SunXiangang Hu
Jun 21, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Melisa Bunderson-SchelvanRaymond F Hamilton
Sep 16, 2021·Nanomedicine·Xi LiSufang Wu