Wogonin attenuates liver fibrosis via regulating hepatic stellate cell activation and apoptosis

International Immunopharmacology
Xiao-Sa DuJun Li

Abstract

Liver fibrosis is the representative features of liver chronic inflammation and the characteristic of early cirrhosis. To date, effective therapy for liver fibrosis is lacking. Recently, Traditional Chinese Medicine (TCM) has attracted increasing attention due to its wide pharmacological effects and more uses in clinical. Wogonin, as one major active constituent of Scutellaria radix, has been reported it plays an important role in anti-inflammatory, anti-cancer, anti-viral, anti-angiogenesis, anti-oxidant and neuro-protective effects. However, the anti-fibrotic effect of wogonin is never covered in liver. In this study, we evaluated the protect effect of wogonin in liver fibrosis. Wogonin significantly attenuated liver fibrosis both in CCl4-induced mice and TGF-β1 activated HSCs. Meanwhile, wogonin can enhances apoptosis of TGF-β1 activated HSC-T6 cell from rat and LX-2 cell from human detected by flow cytometry. Additionally, wogonin can largely enhances cle-caspase3, cle-caspase9 expression and the ratio of Bax/Bcl-2 in T6 cells. Pro-apoptosis effect of wogonin in vivo was further verified in situ. In conclusion, wogonin can attenuate liver fibrosis via regulating the activation and apoptosis of hepatic stellate cells, and ma...Continue Reading

Citations

Apr 19, 2020·International Immunopharmacology·Abdullah Al MamunJian Xiao
Nov 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qian WangPeng Jiang
Jan 1, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Partha PalitNima Rezaei
Jul 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Javad Sharifi-RadWilliam C Cho
Apr 10, 2021·Cell Biology International·De JiChengxi Jiang
Jan 10, 2020·Journal of Agricultural and Food Chemistry·Fan JiangYong-Jiang Xu

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