Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity

International Immunopharmacology
Hua Zi PiaoWon-Ki Kim

Abstract

Previously, we and others have demonstrated that wogonin, an active component from the root of Scutellaria baicalensis Georgi, has a neuroprotective effect in cerebral ischemic insult. The neuroprotective effect of wogonin may at least in part be due to its anti-inflammatory properties. Microglial cells, well-known residential macrophages in the central nervous system, migrate to the ischemic lesion and play a pivotal role in the development of chronic inflammation. In the present study, we observed that wogonin potently inhibited microglial migration toward a chemokine, monocyte chemoattractant protein-1 (MCP-1). The anti-migratory effect of wogonin was provoked at nanomolar concentrations, at which wogonin did not significantly inhibit the production of cytokines and chemokines. NF-kappaB has previously shown to regulate microglial cell migration, and activation of cAMP-signaling pathway has also been associated with inhibition of microglial cell motility. In the present study, wogonin at low micromolar concentrations completely suppressed the activity of NF-kappaB in MCP-1-stimulated microglia, and NF-kappaB inhibitors such as N-acetyl cysteine and pyrrolidinedithiocarbamate inhibited the MCP-1-induced migration of microglia...Continue Reading

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Citations

Jun 30, 2011·European Journal of Drug Metabolism and Pharmacokinetics·Tingting LiQidong You
Sep 6, 2012·International Journal of Molecular Sciences·Cheng-Fang TsaiDah-Yuu Lu
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Nov 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hengfeng LiaoYuling Liu

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