Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects

Cancer Chemotherapy and Pharmacology
Riyo EnomotoEibai Lee

Abstract

Wogonin, a flavone in the roots of Scutellaria baicalensis, reduced etoposide-induced apoptotic cell death in normal cells, such as bone marrow cells and thymocytes. On the other hand, wogonin potentiated the proapoptotic or cytotoxic action of etoposide in tumor cells, such as Jurkat, HL-60, A549, and NCI-H226. These contradictory actions of wogonin on apoptosis are distinguished by normal or cancer cell types. Wogonin had no effect on apoptosis induced by other anticancer agents in the tumor cells. Thus, the potentiation effect of wogonin was observed only in etoposide-induced apoptosis in tumor cells. In a functional assay for P-glycoprotein (P-gp), wogonin suppressed excretion of calcein, a substrate for P-gp, in these tumor cells. Moreover, wogonin decreased the excretion of radiolabeled etoposide and accordingly increased intracellular content of this agent in the cells. P-gp inhibitors showed a similar potentiation effect on etoposide-induced apoptosis in these tumor cells. Thus, wogonin is likely to potentiate the anticancer action of etoposide due to P-gp inhibition and accumulation of this agent. These findings suggest that wogonin may be a useful chemotherapeutic adjuvant to potentiate the pharmacological action of e...Continue Reading

References

Oct 28, 1994·Biochemical and Biophysical Research Communications·F SatoT Sakai
Jul 15, 1994·Biochemical and Biophysical Research Communications·E LeeK Kariya
Sep 1, 1996·Biochemistry and Molecular Biology International·E LeeH Sasaki
Aug 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heasuk LeeKyoungho Suk
Jun 7, 2006·Biological & Pharmaceutical Bulletin·Wei WangXiao-Tang Wang
Apr 4, 2007·Annals of the New York Academy of Sciences·Eibai LeeChiyoko Sugahara
Apr 27, 2007·Biochemistry·Omari J Bandele, Neil Osheroff
May 8, 2007·European Journal of Pharmacology·Denpong PatanasethanontMikihisa Takano
Aug 8, 2007·Natural Product Research·Sujun LiuJian Zhao
Aug 11, 2007·Journal of Pharmacological Sciences·Riyo EnomotoEibai Lee
Oct 25, 2007·International Journal of Cancer. Journal International Du Cancer·Heekyoung ChungGu Kong
Mar 12, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Qiang ZhangZhu-Jun Wang
Apr 2, 2008·Biochemical Pharmacology·Dae-Hee LeeYong J Lee
Jun 26, 2008·European Journal of Pharmacology·Hai-Wei ZhangQing-Long Guo

❮ Previous
Next ❯

Citations

Jan 6, 2011·Cancer Chemotherapy and Pharmacology·Shu-Er ChowJong-Shyan Wang
Jul 23, 2011·Chinese Medicine·Wen TanYitao Wang
Feb 7, 2014·Journal of Biosciences·Ishtiyaq Ahmad Najar, Rakesh Kamal Johri
May 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amer TalbiXijing Chen
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sabry M AttiaSaleh A Bakheet
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saikat DewanjeeMuhammad Zia-Ul-Haq
Jul 23, 2011·Nutrition Research and Practice·Sora HanYoung Yang
Jul 13, 2019·Current Pharmaceutical Design·Shahzad Khan, Mohammad A Kamal
Jul 25, 2019·Current Pharmaceutical Design·Shahzad Khan, Mohammad A Kamal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis