Wolf outside, dog inside? The genomic make-up of the Czechoslovakian Wolfdog

BMC Genomics
Romolo CanigliaMarco Galaverni

Abstract

Genomic methods can provide extraordinary tools to explore the genetic background of wild species and domestic breeds, optimize breeding practices, monitor and limit the spread of recessive diseases, and discourage illegal crossings. In this study we analysed a panel of 170k Single Nucleotide Polymorphisms with a combination of multivariate, Bayesian and outlier gene approaches to examine the genome-wide diversity and inbreeding levels in a recent wolf x dog cross-breed, the Czechoslovakian Wolfdog, which is becoming increasingly popular across Europe. Pairwise FST values, multivariate and assignment procedures indicated that the Czechoslovakian Wolfdog was significantly differentiated from all the other analysed breeds and also well-distinguished from both parental populations (Carpathian wolves and German Shepherds). Coherently with the low number of founders involved in the breed selection, the individual inbreeding levels calculated from homozygosity regions were relatively high and comparable with those derived from the pedigree data. In contrast, the coefficient of relatedness between individuals estimated from the pedigrees often underestimated the identity-by-descent scores determined using genetic profiles. The timing ...Continue Reading

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Methods Mentioned

BETA
chip
Assay
PCA
genotyping

Software Mentioned

BGC Bayesian Genomic Cline analysis
A dmixture
B M ate P edigree E xplorer
Variant Suite
SNP
SVS
PCA dmix
aye S can
R
gProfiler

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