Women infected with human immunodeficiency virus type 1 have poorer assisted reproduction outcomes: a case-control study

Fertility and Sterility
Camille StoraCatherine Patrat

Abstract

To compare the efficacy of assisted reproductive technology (ART) in women infected with human immunodeficiency virus type 1 (HIV-1) versus HIV-negative controls. Retrospective case-control study. University hospital ART unit. Eighty-two women infected with HIV-1 and 82 women as seronegative controls. Ovarian stimulation, oocytes retrieval, standard in vitro fertilization (IVF) or intracytoplasmic sperm injection, embryo transfer. Clinical pregnancies and live-birth rates. After oocyte retrieval, all women infected with HIV-1 infected were matched 1:1 to HIV-negative controls according to the following criteria: date of ART attempt, age, parity, main cause of infertility, ART technique, and rank of attempt. Only the first IVF cycle during the study period was considered for each couple. We found no statistically significant differences between the two groups for ovarian stimulation data, fertilization rate, or average number of embryos transferred. The clinical pregnancy rate per transfer was statistically significantly lower for the cases compared with the controls (12% vs. 32%), as were the implantation rate (10% vs. 21%) and the live-birth rate (7% vs. 19%). In one of the largest studies to pair six factors that influence th...Continue Reading

References

Apr 30, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M WeisserM Egger
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Dec 22, 2007·AIDS·Josiane WarszawskiUNKNOWN ANRS French Perinatal Cohort
Apr 17, 2009·Fertility and Sterility·David B SeiferUNKNOWN Society for Assisted Reproductive Technology Writing Group Report
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Jul 23, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laurent MandelbrotUNKNOWN ANRS-EPF Study Group

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Citations

Dec 12, 2018·AIDS·Elizabeth M KingMelanie C M Murray
Jan 7, 2021·Prenatal Diagnosis·Kristin Harris, Mark H Yudin
Apr 10, 2021·Fertility and Sterility·UNKNOWN Ethics Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org
Feb 13, 2019·Gynécologie, Obstétrique, Fertilité & Sénologie·C NiniveM Peigné

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