Women Undergoing Coronary Angiography for Myocardial Infarction or Who Present With Multivessel Disease Have a Poorer Prognosis Than Men

Angiology
Crystel M GijsbertsHester M den Ruijter

Abstract

Coronary artery disease affects both men and women. In this study, we examine sex-specific differences in occurrence of major adverse cardiovascular events (MACEs) after coronary angiography. We analyzed data from the coronary angiography cohort Utrecht Coronary Biobank (n = 1283 men, 480 women). Using Kaplan-Meier and multivariable Cox-regression, we tested for sex differences in MACE occurrence. Additionally, we compared mortality with an age- and sex-matched control group from the general Dutch population. During a median follow-up of 2.1 years (interquartile range 1.6-2.8), MACEs occurred in 265 men and 103 women (20.7% vs 21.3%, P = .744). Women with myocardial infarction (MI) had significantly more MACE during follow-up than men (hazard ratio [HR] 1.66 for female sex, 95% confidence interval [CI] 1.10-2.50, P = .015), which was also the case for women who had multivessel disease (HR 1.41, 95% CI 1.03-1.94, P = .031). During follow-up, mortality in women presenting with MI was higher than mortality of women in the general population; men with MI did not show this disadvantage. MACEs occurred more often in women than in men who presented with MI or who had angiographic multivessel disease upon coronary angiography. Clinical...Continue Reading

Associated Clinical Trials

Dec 2, 2014·Crystel Gijsberts

References

Jul 20, 2002·The American Journal of Cardiology·Thomas J WangRamachandran S Vasan
Aug 18, 2004·Circulation·Carl J Vaughan, Antonio M Gotto
Feb 7, 2006·Journal of the American College of Cardiology·Gretchen L GierachUNKNOWN WISE Study Group
Oct 17, 2009·Journal of the American College of Cardiology·Leslee J ShawC Noel Bairey Merz
Dec 25, 2009·Circulation. Cardiovascular Interventions·Alice K Jacobs
Feb 24, 2011·JAMA : the Journal of the American Medical Association·Issa J Dahabreh, David M Kent
Mar 11, 2011·Mayo Clinic Proceedings·Marie T Brown, Jennifer K Bussell
Feb 23, 2013·Circulation·Lori MoscaUNKNOWN American Heart Association Cardiovascular Disease and Stroke in Women and Special Populations Committee of the Council on Cl
Apr 30, 2013·American Heart Journal·Jennifer LeweyNiteesh K Choudhry
Jan 16, 2014·Circulation. Cardiovascular Quality and Outcomes·Alison L SullivanHarry P Selker
May 3, 2014·Circulation·Venkatesh L MurthyMarcelo F Di Carli
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 6, 2015·European Journal of Clinical Investigation·Manon G van der MeerYolande Appelman
Jan 24, 2015·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·H den RuijterD P V de Kleijn
Feb 12, 2015·Atherosclerosis·Yolande AppelmanSanne A E Peters

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
coronary artery bypass

Clinical Trials Mentioned

NCT02304744

Software Mentioned

R
SYNTAX score calculator

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