Women with a nondiagnostic 75 g glucose tolerance test but elevated HbA1c in pregnancy: an additional group of women with gestational diabetes

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Janet A RowanLynn C Sadler

Abstract

We examined whether pregnant women with a normal glucose tolerance test (OGTT) by New Zealand (NZ) criteria, but elevated HbA1c are a clinically important group with gestational diabetes (GDM). Eighty women with a normal OGTT and HbA1c > 40 mmol/mol, compared with others with GDM, had a significantly higher BMI and were more likely Pacific. Pharmacotherapy was prescribed in 77.5%. Post-partum OGTT and HbA1c were abnormal in 9/43(20.9%) and 27/42(64.3%), respectively. In 1090 women being screened for GDM by OGTT, most women with GDM had an HbA1c ≤ 40 mmol/mol. In the 22.1% of women with an HbA1c > 40 mmol/mol, the OGTT was normal in 61.8%. For centres using HbA1c to screen for underlying prediabetes/diabetes, these data show that a result >40 mmol/mol identifies women who are likely to require pharmacotherapy. An OGTT is still recommended to diagnose GDM, but these data raise questions about a possible role for HbA1c in high risk women with a nondiagnostic OGTT.

References

Feb 1, 1990·Journal of Internal Medicine·P Gram-HansenL Olesen
Oct 1, 1993·American Journal of Obstetrics and Gynecology·P M CatalanoS B Amini
Apr 28, 2004·Diabetes Care·Lene R NielsenElisabeth R Mathiesen
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Mar 2, 2010·Diabetes Care·UNKNOWN International Association of Diabetes and Pregnancy Study Groups Consensus PanelMaria Ines Schmidt
Jun 18, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·J E L GohJ Rowan
Feb 4, 2012·Diabetes Care·Lynn P LoweUNKNOWN HAPO Study Cooperative Research Group
Apr 28, 2012·Clinical Chemistry·Regina EnsenauerRüdiger von Kries

❮ Previous
Next ❯

Citations

Jun 3, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·J A RowanL C Sadler
Feb 14, 2015·Primary Care Diabetes·Sahar Ali Ibrahim Hammouda, Rubina Hakeem
Feb 18, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Janet RowanNicole McGrath
Aug 21, 2015·PloS One·Paula Breitenbach RenzJoíza Lins Camargo
May 4, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Oleg Petrović, Dragan Belci
Nov 3, 2017·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Ruth C E HughesJoanna E Gullam
Oct 27, 2018·Journal of Clinical Pathology·Leon CampbellKate Shipman
Aug 3, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hatice Kansu-CelikYaprak Engin-Ustun
Jun 10, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·N M McGrathA Simkins
Feb 24, 2017·Current Diabetes Reports·Camille E Powe
Jan 8, 2016·Current Diabetes Reports·Ruth C E HughesChris M Florkowski
May 14, 2021·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Yuxin LimLesley M E McCowan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.