Women with functional hypothalamic amenorrhea but not other forms of anovulation display amplified cortisol concentrations

Fertility and Sterility
Sarah L BergaD E Giles

Abstract

To test the hypothesis that increased cortisol secretion is specific to women with decreased GnRH drive and not found in eumenorrheic women or those with other causes of anovulation. Cortisol concentrations in blood were determined at 30-minute intervals for 24 hours in three well-characterized groups: women with functional hypothalamic amenorrhea, those with other causes of anovulation, and eumenorrheic women. Academic medical center. Women aged 20 through 35 years, with well-defined reproductive states. Venous blood samples were obtained from, and psychometric inventories were completed by, the participants. Twenty-four-hour cortisol levels, 24-hour LH pulse patterns, and serial P levels were measured in women with functional hypothalamic amenorrhea, eumenorrheic women, and those with other causes of anovulation. Cortisol secretion was higher in women with functional hypothalamic amenorrhea (n = 19) than in those with other causes of anovulation (n = 19) or eumenorrheic women (n = 19). Six women who recovered from functional hypothalamic amenorrhea had cortisol levels comparable to those of eumenorrheic women and those with other causes of anovulation. These data underscore the association between increased hypothalamic-pitui...Continue Reading

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Citations

Dec 15, 2012·European Journal of Applied Physiology·Yoram EpsteinYuval Heled
Oct 22, 2008·Molecular Neurobiology·Cynthia L BetheaJudy L Cameron
Jul 31, 2001·Fertility and Sterility·M D MarcusS L Berga
Oct 15, 2003·Fertility and Sterility·Walter Tschugguel, Sarah L Berga
Jul 31, 1999·Fertility and Sterility·N H HjollundJ Olsen
Jan 14, 2000·Psychoneuroendocrinology·V HendrickS Korenman
Feb 11, 2003·Journal of the American College of Cardiology·C Noel Bairey MerzUNKNOWN WISE Study Group
Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Jan 20, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eydie L Moses-KolkoWayne C Drevets
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sharon H ChouChristos S Mantzoros
Apr 28, 2004·ILAR Journal·Jay R Kaplan, Stephen B Manuck
Jun 7, 2003·The Clinical Journal of Pain·Anna Maria Aloisi
Feb 22, 2000·Annals of the New York Academy of Sciences·J R Kaplan, S B Manuck
Sep 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·S M HerodJ L Cameron
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Elizabeth A LawsonAnne Klibanski
Sep 10, 2014·Journal of Endocrinological Investigation·B MeczekalskiM Maciejewska-Jeske
Feb 6, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M KyriakidisH Lashen
Aug 14, 2012·Fertility and Sterility·Rebecca J ChasonGermaine M Buck Louis
Dec 24, 2011·Fertility and Sterility·Stephen Franks, Sarah L Berga
Aug 9, 2011·Fertility and Sterility·Olivier CosteCharles Sultan
Aug 14, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lina Michala, Aris Antsaklis
Mar 10, 2016·Hormone Molecular Biology and Clinical Investigation·Heather C M AllawayMary Jane De Souza
Sep 16, 2010·Annals of the New York Academy of Sciences·Samuel A Pauli, Sarah L Berga
Feb 20, 2007·Annals of the New York Academy of Sciences·Sarah L Berga, Tammy L Loucks
Jan 30, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cynthia L BetheaJudy L Cameron
Jan 31, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sarah Berga, Frederick Naftolin
May 16, 2014·Journal of Psychosomatic Obstetrics and Gynaecology·Simona Palm-Fischbacher, Ulrike Ehlert
Apr 14, 2000·American Journal of Obstetrics and Gynecology·S L BergaM D Marcus

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