PMID: 6407808Jul 1, 1983Paper

"Won't breathe" vs "can't breathe". Detection of depressed ventilatory drive in patients with obstructive pulmonary disease

Chest
P J Fahey, R W Hyde

Abstract

Impaired pulmonary mechanics or depression of the respiratory centers can limit the ventilatory response to inhaled carbon dioxide in patients with chronic obstructive pulmonary disease (COPD). We devised a method able to detect depressed neurogenic and chemical ventilatory drive during expiratory airflow obstruction. In 14 normal subjects, we impeded expiratory airflow while measuring the resultant decline in maximum voluntary ventilation (MVV) and the ventilatory response to rebreathing 7 percent CO2 (delta V/delta PCO2). The MVV and delta V/delta PCO2 fell proportionately and were closely correlated (r = 0.88). The lower limit for delta V/delta PCO2 during airway obstruction equalled 1.2 L/min/mm Hg X (observed MVV divided by predicted MVV). Nine patients with COPD and normal arterial carbon dioxide tension (PaCO2) all had normal values for delta V/delta PCO2 corrected for MVV; however, nine of 12 patients with COPD and elevated PaCO2 and bicarbonate levels had depressed values for delta V/delta PCO2. These data indicate that neurogenic and chemical depression to ventilation can be detected in patients with mechanical obstruction to expiratory airflow if delta V/delta PCO2 is corrected for changes in MVV.

References

Jul 1, 1972·The American Review of Respiratory Disease·R M Cherniack, M B Raber
Jan 1, 1971·The Journal of Clinical Investigation·M B GoldsteinW B Schwartz
Jul 11, 1968·The New England Journal of Medicine·R V Lourenço, J M Miranda

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Citations

Sep 9, 2006·European Journal of Applied Physiology·Jack A LoeppkyStephen A Altobelli
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·D IluchevS Lazarov
Jul 1, 1988·The American Review of Respiratory Disease·F D McCoolR W Hyde
Oct 1, 1988·The American Review of Respiratory Disease·J P DerenneR Pariente
Mar 13, 2014·Respiratory Medicine·Christopher Matthew Norton EaringHans-Peter Kubis
Apr 20, 2001·The American Journal of the Medical Sciences·S M Koenig
May 29, 2007·Respiratory Physiology & Neurobiology·F XuT H March
Dec 8, 2006·Pulmonary Pharmacology & Therapeutics·Agnieszka CiarkaPhilippe van de Borne
Jul 31, 1998·Archives of Physical Medicine and Rehabilitation·K H LinY H Wang
Apr 22, 2015·Respiratory Physiology & Neurobiology·Chi-Sang PoonGang Song
Aug 19, 2008·Toxicology and Applied Pharmacology·Jianguo ZhuangMohan L Sopori
May 1, 1987·Chest·F L GlauserD Bechard
Jul 17, 2004·European Journal of Clinical Investigation·A CiarkaP van de Borne
Nov 1, 1987·The Annals of Thoracic Surgery·W G Wolfe

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