Wood smoke exposure of Portuguese wildland firefighters: DNA and oxidative damage evaluation

Journal of Toxicology and Environmental Health. Part a
Ana AbreuSolange Costa

Abstract

Portugal is among the European Union countries most devastated by forest fires each year. In the last three decades, more than 3.8 million hectares of forest were burned. Wildland firefighters are exposed to a variety of hazards, including many toxic combustion products that may lead to deleterious health effects. Epidemiological studies showed a positive association between firefighting and several chronic diseases, including cancer. Results from biomonitoring studies in firefighters, particularly concerning genotoxicity evaluation, constitute a valuable tool for investigating important occupational hazards. Thus, the aim of this study was to assess genotoxicity in a group of wildland firefighters using the comet assay for DNA damage and oxidative stress. Both parameters were increased in firefighters compared to controls, but significance was only found for basal DNA damage. No significant influence was found regarding major confounding variables on the genotoxic endpoints studied, with the exception of age. Data obtained provide preliminary information on human health effects of wildland firefighting exposure at genetic and molecular levels. These findings may also provide new important data to serve as public awareness to t...Continue Reading

References

Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
Jan 1, 1995·Annual Review of Public Health·J M LinksJ D Groopman
Feb 24, 2001·Endodontics & Dental Traumatology·J D ReganK Gulabivala
Aug 3, 2001·Journal of Toxicology and Environmental Health. Part a·C C AustinG Dussault
Jun 6, 2002·Medicine and Science in Sports and Exercise·Brent C RubySonja Tysk
Aug 7, 2002·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Judith T ZelikoffRichard B Schlesinger
Jan 31, 2004·Toxicology·Myung S ParkMichael A Dubick
Jun 19, 2004·Journal of Occupational and Environmental Hygiene·James C SlaughterTimothy E Reinhardt
Jun 21, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Po-Len LiuYu Ru Kou
May 17, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Micheline Kirsch-VoldersMichael Fenech
Nov 28, 2006·Inhalation Toxicology·Luke P NaeherKirk R Smith
May 8, 2007·Toxicology·Stephen S LeonardDenise M Gaughan
Aug 21, 2007·Occupational and Environmental Medicine·L BarregardA-C Olin
Jan 8, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Klaus Golka, Wobbeke Weistenhöfer
Feb 8, 2008·The European Respiratory Journal·J R SwistonS F van Eeden
May 23, 2008·Mutation Research·Pernille Høgh DanielsenSteffen Loft
Jun 24, 2008·Inhalation Toxicology·M StefanidouC Spiliopoulou
Sep 12, 2008·Journal of Occupational and Environmental Medicine·Denise M GaughanDavid N Weissman
Jun 29, 2010·Environment International·Ana Isabel MirandaLuís Paulo Pita
Apr 23, 2011·Vascular Medicine·Christopher A FahsBo Fernhall
Jun 11, 2011·Free Radical Biology & Medicine·Kamla Al-SalmaniMarcus S Cooke
Jun 29, 2011·Journal of Toxicology and Environmental Health. Part a·Solange CostaJoão Paulo Teixeira
Jul 14, 2012·Journal of Toxicology and Environmental Health. Part a·Ana Isabel MirandaRoger Ottmar
Feb 1, 2013·Journal of Occupational and Environmental Hygiene·Anna M HejlLuke P Naeher
Feb 26, 2013·The Science of the Total Environment·Olorunfemi AdetonaLuke P Naeher
May 21, 2013·Archives of Toxicology·Amaya Azqueta, Andrew R Collins
Sep 13, 2013·Toxicology Mechanisms and Methods·Carlos RamosM Montaño
Nov 5, 2013·Mutation Research. Reviews in Mutation Research·Andrew CollinsUNKNOWN ComNet project
May 16, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gerard M Cooke
Jun 4, 2014·Environmental and Molecular Mutagenesis·Annie JensenPeter Møller
Jun 10, 2014·American Journal of Industrial Medicine·Denise M GaughanDavid C Christiani
Jul 22, 2014·Conservation Biology : the Journal of the Society for Conservation Biology·Brian K SullivanMatthew A Kwiatkowski
Dec 17, 2014·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Beatriz Fátima Alves de OliveiraSandra Hacon
Dec 21, 2014·Mutagenesis·Monica NeriStefano Bonassi
Jan 29, 2016·Journal of Toxicology and Environmental Health. Part a·Carlos Fernando CamposBoscolli Barbosa Pereira
Feb 27, 2016·Inhalation Toxicology·Olorunfemi AdetonaLuke P Naeher
Oct 31, 2016·International Journal of Hygiene and Environmental Health·Marta OliveiraSimone Morais

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