PMID: 9539236Apr 16, 1998Paper

Word reading in Alzheimer's disease: cross-sectional and longitudinal analyses of response time and accuracy data

Neuropsychologia
E StrainJ R Hodges

Abstract

Using a list of high- and low-frequency regular and exception words, we measured the reading performance of three groups of subjects: patients with mild dementia of the Alzheimer's type (DAT) at presentation (Stage 1) and 2-3 years later (Stage 2); moderately severe DAT patients; and control subjects. In the longitudinally studied patients, there was a dramatic increase in response times (RTs) from Stage 1 to Stage 2, but little change in either error rate or pattern. By contrast, a comparison of the Stage 2 with the Moderate patients revealed similar RTs but a significant increase in error rate for the Moderate group, particularly on low-frequency exception words. These two results for word naming were almost exactly mirrored by effects in picture naming. We conclude that correct word reading, especially for less common words with atypical spelling-sound correspondences, is compromised in DAT only when the disease produces a significant deterioration of semantic memory. These results are relevant to current theories about normal and impaired reading processes.

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Citations

Feb 24, 2001·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·L ColomboS F Capp
Mar 20, 2002·Neuropsychologia·Guila GlosserChristopher M Clark
Oct 17, 2003·Brain Research. Cognitive Brain Research·Fernando CuetosAndrew W Ellis
Oct 7, 2004·Journal of Experimental Psychology. Human Perception and Performance·Christopher T Kello
Nov 22, 2008·Brain : a Journal of Neurology·Stephen M WilsonMaria Luisa Gorno-Tempini
Nov 19, 2009·Cerebral Cortex·William W GravesJeffrey R Binder
Dec 8, 1998·Neuropsychologia·M BehrmannE B Sekuler
Jun 3, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M-P OryszczynUNKNOWN EGEA cooperative group
May 12, 2009·Neuropsychologia·S M BrambatiM L Gorno-Tempini
Oct 27, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jean-Sebastien ProvostMaximiliano A Wilson
Feb 13, 2009·Chronobiology International·Jennifer Urbano BlackfordNiels G Waller
Nov 16, 2005·Brain Injury : [BI]·J A B MacnivenB A Wilson
Jul 29, 2017·Brain and Cognition·Tamar H GollanDavid P Salmon
Sep 22, 2009·Neuropsychologia·Elizabeth JefferiesMatthew A Lambon Ralph
Jun 10, 2021·Current Alzheimer Research·María Del Carmen Pérez-SánchezMarta Álvarez-Cañizo

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