Work Intensity, Low-Grade Inflammation, and Oxidative Status: A Comparison between Office and Slaughterhouse Workers

Oxidative Medicine and Cellular Longevity
Sieglinde ZelzerHarald Mangge

Abstract

Limited knowledge exists about the impact of physical workload on oxidative stress in different occupational categories. Thus, we aimed to investigate the oxidative and inflammatory status in employees with different physical workloads. We enrolled a total of 79 male subjects, 27 office workers (mean age 38.8 ± 9.1 years) and 52 heavy workers, in a slaughterhouse (mean age 40.8 ± 8.2 years). Fasting blood was drawn from an antecubital vein in the morning of the midweek before an 8-hour or 12-hour work shift. The antioxidative capacity was assessed measuring total antioxidant capacity (TAC), uric acid, total polyphenols (PPm), and endogenous peroxidase activity (EPA). Total peroxides (TOC), malondialdehyde (MDA), and myeloperoxidase (MPO) were analyzed as prooxidative biomarkers, and an oxidative stress index (OSI) was calculated. In addition, hsCRP, interleukin-6 (IL-6), MDA-LDL IgM antibodies, galectin-3, adrenocorticotropic hormone (ACTH), and the brain-derived neurotrophic factor (BDNF) were measured as biomarkers of chronic systemic inflammation and emotional stress. TOC (p = 0.032), TAC (p < 0.001), ACTH (p < 0.001), OSI (p = 0.011), and hsCRP (p = 0.019) were significantly increased in the heavy workers group, while EPA, ...Continue Reading

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Citations

Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Martha A Sánchez-Rodríguez, Víctor Manuel Mendoza-Núñez
Jan 20, 2021·International Journal of Occupational Safety and Ergonomics : JOSE·Jamal BiganehMajid Bagheri Hosseinabadi
Apr 17, 2021·International Journal of Food Sciences and Nutrition·Ratih W WisnuwardaniNathalie Michels

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

Stata
SPSS

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