Work of breathing during CPAP and heated humidified high-flow nasal cannula

Archives of Disease in Childhood. Fetal and Neonatal Edition
Sandeep ShettyAnne Greenough

Abstract

To determine whether continuous positive airway pressure (CPAP) compared with heated humidified, high-flow nasal cannula (HHFNC) in infants with evolving or established bronchopulmonary dysplasia (BPD) reduced the work of breathing (WOB) and thoracoabdominal asynchrony (TAA) and improved oxygen saturation (SaO2). Randomised crossover study. Tertiary neonatal unit. 20 infants (median gestational age of 27.6 weeks (range 24.6-31.9 weeks)) were studied at a median postnatal age of 30.9 weeks (range 28.1-39.1 weeks). Infants were studied on 2 consecutive days. On the first study day, they were randomised to either CPAP or HHFNC each for 2 h, the order being reversed on the second day. The WOB was assessed by measuring the pressure time product of the diaphragm (PTPdi). PTPdi, TAA and SaO2 were assessed during the final 5 min of each 2 h period and the results on the two study days were meaned. There were no significant differences in the results on CPAP versus HHFNC: mean PTPdi 226 (range 126-294) versus 224 cm H2O/s/min (95% CI for difference: -27 to 22; p=0.85) (range 170-318) (p=0.82), mean TAA 13.4° (range 4.51°-23.32°) versus 14.01° (range 4.25°-23.86°) (95% CI for difference: -3.9 to 2.8: p=0.73) (p=0.63) and mean SaO2 95% (r...Continue Reading

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References

May 12, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·J G SaslowK H Pyon
Nov 9, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·D J WilkinsonJ Holberton
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May 3, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anna LavizzariRaffaele L Dellacà

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Citations

Oct 31, 2018·European Journal of Pediatrics·Elinor CharlesAnne Greenough
Jan 8, 2019·Journal of Paediatrics and Child Health·Kate A HodgsonLouise S Owen
Sep 21, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Ashley NievesAlan M Groves
Jun 28, 2019·Expert Review of Respiratory Medicine·Emma Williams, Anne Greenough
Sep 15, 2017·Maternal Health, Neonatology and Perinatology·Calum T Roberts, Kate A Hodgson
Dec 24, 2019·Pediatric Pulmonology·Judith L HoughAndreas Schibler
Jul 1, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Benjamin DudoignonBrigitte Fauroux

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