Work overload induced changes in fast and slow skeletal muscle myosin heavy chain gene expression.

FEBS Letters
M J Morgan, P T Loughna

Abstract

Work induced hypertrophy of the slow postural soleus and the fast phasic plantaris muscles was produced by tenotomy of the synergistic gastrocnemius muscle. Increases in weight of both muscles were associated with proportionately even larger increases in total RNA and mRNA levels. Alterations in levels of specific myosin heavy chain (MHC) isoform mRNAs were measured using the slot blot procedure with radioactively labelled oligonucleotides as probes. Type 1 MHC gene expression was unaffected in both muscles by work overload, whereas type 2a was deinduced in the soleus and type 2b was deinduced in the plantaris. The neonatal MHC gene was transiently reinduced in the plantaris.

References

Jun 1, 1986·Medicine and Science in Sports and Exercise·V MahdaviB Nadal-Ginard
Aug 15, 1986·The Biochemical Journal·P GregoryW S Stirewalt
Jul 1, 1967·The Journal of General Physiology·M Bárány

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Citations

Jun 16, 2012·The Journal of Physiological Sciences : JPS·Bradley S GordonMatthew C Kostek
Sep 1, 1991·Biochimie·T ErdosL Rappaport
Dec 1, 1991·Trends in Cardiovascular Medicine·R H Karas, R S Williams
Nov 3, 2010·Biological Reviews of the Cambridge Philosophical Society·Kristian Gundersen
May 4, 2012·The Angle Orthodontist·Charles WidmerJoyce Morris-Wiman
Jun 30, 2000·Biochemical and Biophysical Research Communications·S BayolC Brownson
Aug 5, 2016·American Journal of Physiology. Cell Physiology·Einar EftestølJo C Bruusgaard
Sep 22, 2000·Microscopy Research and Technique·D Pette, R S Staron
Feb 11, 2003·Journal of Applied Physiology·Laurence StevensYvonne Mounier

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