Workers of São Paulo city, Brazil, exposed to air pollution: Assessment of genotoxicity

Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Daniel Siquieroli Vilas BoasMônica Valéria Marquezini

Abstract

Air pollution affects all major urban centers, particularly megacities with populations greater than 10 million people. Vehicular and industrial emissions are among the most important sources of air pollutants in these cities. Air pollution composition, dose, and time of exposure can cause differential effects on human health. We have evaluated the genotoxic effects of air pollution (PM2.5 and NO2) on São Paulo city workers. Fifty-seven male individuals, 28-66 years old, with occupational exposure to air pollution, participated in this study; all worked daily outdoor shifts in São Paulo. Participants were recruited from three occupations: traffic controllers (n = 18); taxi drivers (n = 21); and workers at the Forestry Institute (n = 18). These workers were classified into two groups based on their workplace locations: Downtown Group (DT): traffic controllers and taxi drivers; Outskirts of Town Group (OT): workers at the Forestry Institute. Individual samplers of air pollution (Harvard air impactor) were used to collect PM2.5 and NO2 pollutants. Genotoxicity analysis (micronucleus test) was performed on buccal mucosa epithelial cells and peripheral blood lymphocytes. PM2.5 concentrations were significantly different between the ...Continue Reading

Citations

Jan 22, 2020·Journal of Applied Toxicology : JAT·Natália BruckerSolange Cristina Garcia
Nov 27, 2020·Toxicology and Industrial Health·Flavio Manoel Rodrigues da Silva JúniorEdariane Menestrino Garcia
Jun 1, 2019·Chemosphere·Milena Simões PeixotoSilvia Regina Batistuzzo de Medeiros
Nov 30, 2021·Journal of Toxicology and Environmental Health. Part a·Jaime Luna-CarrascalJesus Olivero-Verbel

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