Working Group report 3: sensitivity to organic dusts--atopy and gene polymorphisms

American Journal of Industrial Medicine
Joel N KlineRihong Zhai

Abstract

Working Group 3 (Sensitivity to Organic Dusts-Atopy and Gene Polymorphisms) was convened to review the current understanding of how effects of inhaled organic dust may be modified by genetic factors-both those that increase as well as those that may reduce susceptibility. Furthermore, the group was asked to suggest areas that require more investigation in this field. The discussion focused on individual sensitivity to inhaled agents as the most important determinant of inter-individual heterogeneiety in responses to exposures. Genetic modifiers are known for a number of pathologic conditions (including asthma, atopy, chronic obstructive pulmonary disease, and hypersensitivity pneumonitis) associated with inhalation of organic dusts; modifiers are likely to be identified for a number of other disease states. Further studies are required to delineate more precisely the contribution (and the role in inflammatory cascade modulation) of these known polymorphisms, as well as to identify novel genetic factors.

References

Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·J N KlineD A Schwartz
Jun 3, 2000·Nature Genetics·N C ArbourD A Schwartz
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Benjamin A RabyScott T Weiss
Dec 21, 2002·Immunological Reviews·William Cookson
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Olivier MichelRagnar Rylander

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Citations

Mar 27, 2007·Environmental Health Perspectives·Kelley J DonhamPeter S Thorne
Oct 25, 2011·American Journal of Public Health·Paul A SchulteHeeKyoung Chun
Jan 16, 2007·Chest·Liliane ChénardJames A Dosman
Jun 9, 2007·The Journal of Allergy and Clinical Immunology·Jill A PooleDebra J Romberger
Mar 15, 2005·Current Opinion in Allergy and Clinical Immunology·Cristina E Mapp

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