Working memory consolidation is abnormally slow in schizophrenia

Journal of Abnormal Psychology
Rebecca L FullerJames Gold

Abstract

This study reports evidence that patients with schizophrenia demonstrate a slowing of working memory (WM) consolidation, which is the process of transforming transient perceptual representations into durable WM representations. Sixteen schizophrenia patients and 16 healthy control participants performed a task measuring the visual WM consolidation rate in a change-detection paradigm. A target display containing 3 colored squares was followed by a variable delay of 17-483 ms, a pattern mask, and then a test stimulus. This pattern mask does not interfere with perception but disrupts WM consolidation. Control participants reached no-mask performance by 250 ms, indicating completed WM consolidation, whereas patients failed to reach no-mask performance by 483 ms. Slowed consolidation may play an important and largely unrecognized role in schizophrenia.

References

Jan 1, 1978·Journal of Psychiatric Research·T F OltmannsJ M Neale
Jan 1, 1978·Journal of Psychiatric Research·L J Chapman, J P Chapman
Dec 1, 1992·Archives of General Psychiatry·Sohee Park, P S Holzman
Jan 1, 1992·Schizophrenia Bulletin·T KojimaY Shimazono
Jan 1, 1992·European Archives of Psychiatry and Clinical Neuroscience·E MatsushimaY Shimazono
Jun 1, 1973·Psychological Bulletin·L J Chapman, J P Chapman
May 1, 1984·Journal of Abnormal Psychology·D S Wells, D Leventhal
Oct 1, 1995·Archives of General Psychiatry·Sohee ParkP S Goldman-Rakic
Mar 27, 1995·Psychiatry Research·K FlemingD R Weinberger
Feb 1, 1995·Journal of Experimental Psychology. Human Perception and Performance·M M Chun, M C Potter
Dec 1, 1994·Archives of General Psychiatry·M F GreenJ Mintz
Mar 1, 1996·The American Journal of Psychiatry·M F Green
May 1, 1996·The American Journal of Psychiatry·B F O'DonnellR W McCarley
May 1, 1996·Schizophrenia Research·R CondrayA Kasparek
Jan 1, 1997·Biological Psychiatry·K FlemingD R Weinberger
Feb 1, 1997·Archives of General Psychiatry·J M GoldD R Weinberger
Feb 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H CallicottD R Weinberger
May 8, 1998·Psychological Medicine·S B HuttonEileen M Joyce
Aug 29, 1998·Cognitive Psychology·P Jolicoeur, R Dell'Acqua
Oct 21, 1998·Journal of Experimental Psychology. Human Perception and Performance·B Giesbrecht, V Di Lollo
Nov 18, 1998·Archives of General Psychiatry·P C FletcherR J Dolan
Sep 25, 1999·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·H Stanislaw, N Todorov
Mar 20, 2001·Archives of General Psychiatry·D M BarchJ D Cohen
Jun 30, 2001·The American Journal of Psychiatry·W M PerlsteinJ D Cohen
Feb 5, 2002·Archives of General Psychiatry·Cenk TekRobert W Buchanan
Mar 21, 2002·Acta Neurologica Scandinavica·H RyuH Maeda
Jul 13, 2002·American Journal of Medical Genetics·Annamari Tuulio-HenrikssonJouko Lönnqvist
Aug 9, 2002·Neuroreport·Chiang-shan Ray LiYing-cheng Chen
Aug 30, 2002·Psychonomic Bulletin & Review·P Jolicoeur
Jan 7, 2003·Archives of General Psychiatry·Angus W MacDonaldCameron S Carter
Mar 5, 2003·Psychonomic Bulletin & Review·Edward K Vogel, Steven Luck
Apr 8, 2003·Biological Psychiatry·David C GlahnTyrone D Cannon
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas W WeickertDaniel R Weinberger
Dec 13, 2006·Journal of Experimental Psychology. Human Perception and Performance·Edward K VogelSteven Luck

Citations

Oct 7, 2010·The Quarterly Journal of Experimental Psychology : QJEP·Huiming SunXiaolan Fu
Jun 9, 2007·Schizophrenia Bulletin·Richard W J Neufeld
Jan 8, 2010·Schizophrenia Bulletin·Britta HahnJames Gold
Dec 6, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ivan KoychevEmma Barkus
Jul 30, 2010·Psychiatry Research·Raymond C K ChanEric F C Cheung
Oct 27, 2009·Psychiatry Research·Peter BachmanTyrone D Cannon
Dec 3, 2008·Psychiatry Research·Adriano ZanelloMarco C G Merlo
Oct 20, 2006·Schizophrenia Research·Carmel M LoughlandAnthony W Harris
Mar 1, 2013·Early Intervention in Psychiatry·Tonya WhiteCanan Karatekin
Oct 18, 2005·Schizophrenia Research·Junghee Lee, Sohee Park
May 12, 2015·Acta Neuropsychiatrica·Brooke M GelderPeter W Schofield
May 12, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Canan KaratekinTonya White
Sep 8, 2010·Behavioural Brain Research·Corinna Haenschel, David Linden
Jan 25, 2018·Cerebral Cortex·Tobias Feldmann-Wüstefeld, Edward K Vogel
May 1, 2018·Annals of the New York Academy of Sciences·Lison FanuelSophie Portrat

Related Concepts

Memory Loss
Schizophrenia
Schizophrenic Psychology

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.