Working Memory Deficit as a Risk Factor for Severe Apathy in Schizophrenia: A 1-Year Longitudinal Study

Schizophrenia Bulletin
Stéphane RaffardDelphine Capdevielle

Abstract

Apathy, described as impaired motivation and goal-directed behavior, is a common yet often overlooked multidimensional psychopathological state in schizophrenia. Its underlying cognitive processes remain largely unexplored. Data was drawn from a longitudinal hospital study of patients with a DSM-IV diagnosis of schizophrenia; 137 (82.5%) participated at the 1-month follow-up and 81 (59.1%) at the 1-year follow-up. Apathy was assessed with the Lille Apathy Rating Scale, validated in French and in schizophrenia. Severe apathy, overall (total score > -13) and on 4 previously identified distinct dimensions, was considered. Episodic verbal learning was assessed with the California Verbal Learning Test, executive functioning with the Trail Making Test, the Six Element Test and the Stop Signal Paradigm and working memory with the Letter-Number Sequencing Test. After controlling for confounding variables, only episodic verbal learning was associated with severe overall apathy in the cross-sectional study. At 1 year, working memory was associated with an increased risk of severe overall apathy, adjusting for baseline apathy. Using a dimensional approach to apathy, specific types of cognition were found to be associated with specific dim...Continue Reading

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Citations

Dec 16, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Annabelle ArnouldMartial Van der Linden
Jun 24, 2018·European Archives of Psychiatry and Clinical Neuroscience·Wing Chung ChangEric Yu Hai Chen
Jun 28, 2018·European Archives of Psychiatry and Clinical Neuroscience·Stéphane RaffardDelphine Capdevielle
May 1, 2020·Schizophrenia Research·Mariia KaliuzhnaStefan Kaiser
Jun 14, 2020·Neuroscience and Biobehavioral Reviews·Indrit BègueMatthias Kirschner

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