Working memory disturbances occur in various psychiatric disorders and play a major role for general cognitive ability in everyday life and thus social integration of the patients. In schizophrenia and bipolar disorder, working memory deficits have been found to be associated with certain genotypes and clinical symptoms. This makes them promising endophenotypes, i.e., mediators between genotype and phenotype. Furthermore recent studies indicate that the identification of selective deficits in working memory may be useful in order to define patient subgroups that are more homogenous with respect to the functional integrity or dysfunction of neural systems underlying working memory subcomponents. This scientific approach may ultimately lead to better understanding of the pathophysiologic mechanisms underlying working memory dysfunctions in psychiatric disorders and may provide clinicians with additional information for diagnostic and therapeutic decisions.
Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression
Neuropsychological and oculomotor correlates of spatial working memory performance in schizophrenia patients and controls
Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?
Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery
Working memory in schizophrenia and mania: correlation with symptoms during the acute and subacute phases
Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings
Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: a meta-analysis
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia
Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex
Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory
Improvement of working but not declarative memory is correlated with HPA normalization during antidepressant treatment
Neurocognitive function in unaffected first-degree relatives of patients with bipolar disorder: a preliminary report
Changes in neuronal activation in patients with bipolar disorder during performance of a working memory task
Neural correlates of working memory deficits in schizophrenic patients. Ways to establish neurocognitive endophenotypes of psychiatric disorders
Selective cognitive deficits in obsessive-compulsive disorder compared to panic disorder with agoraphobia
Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia
Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis
Articulatory rehearsal in verbal working memory: a possible neurocognitive endophenotype that differentiates between schizophrenia and schizoaffective disorder
Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.