Working memory for conjunctions relies on the medial temporal lobe.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ingrid R OlsonMieke Verfaellie

Abstract

A prominent theory of hippocampal function proposes that the hippocampus is importantly involved in relating or binding together separate pieces of information to form an episodic representation. This hypothesis has only been applied to studies of long-term memory because the paradigmatic view of the hippocampus is that it is not critical for short-term forms of memory. However, relational processing is important in many working memory tasks, especially tasks using visual stimuli. Here, we test the hypothesis that the medial temporal lobes are important for relational memory even over short delays. The task required patients with medial temporal lobe amnesia and controls to remember three objects, locations, or object-location conjunctions over 1 or 8 s delays. The results show that working memory for objects and locations was at normal levels, but that memory for conjunctions was severely impaired at 8 s delays. Additional analyses suggest that the hippocampus per se is critical for accurate conjunction working memory. We propose that the hippocampus is critically involved in memory for conjunctions at both short and long delays.

References

Jan 1, 1976·Neuropsychologia·G Winocur, L Weiskranitz
Nov 1, 1987·Neurobiology of Aging·P D Coleman, D G Flood
Jan 1, 1997·Hippocampus·K HenkeH G Wieser
Sep 23, 1998·Hippocampus·E A BuffaloL R Squire
Oct 8, 1999·Behavioural Brain Research·H Eichenbaum
Sep 9, 2000·Brain Research. Cognitive Brain Research·K J MitchellM D'Esposito
Oct 3, 2000·Psychology and Aging·K J MitchellM D'Esposito
Sep 5, 2001·Learning & Memory·C E Stark, L R Squire
Dec 12, 2001·Neuron·T J Druzgal, M D'Esposito
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lila DavachiAnthony D Wagner
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Oct 3, 2003·Nature Reviews. Neuroscience·Alan Baddeley
Nov 15, 2003·Neuropsychologia·Charan RanganathMark D'Esposito
Dec 16, 2003·Cognitive, Affective & Behavioral Neuroscience·Kelly Sullivan GiovanelloMargaret M Keane
Jan 20, 2004·Neuropsychologia·Patrizia TurrizianiGiovanni A Carlesimo
Jan 20, 2004·Neuropsychologia·Jennifer D Ryan, Neal J Cohen
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iain A WilsonHeikki Tanila
Sep 24, 2004·Hippocampus·C Brock Kirwan, Craig E L Stark
Oct 7, 2004·Journal of Experimental Psychology. Human Perception and Performance·Jennifer D Ryan, Neal J Cohen
Apr 16, 2005·Current Opinion in Neurobiology·Charan Ranganath, Mark D'Esposito

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Citations

Oct 6, 2007·Cognitive Processing·Mary Rudner, Jerker Rönnberg
May 15, 2012·Neuropsychology Review·Roy P C Kessels, Michael D Kopelman
Jul 23, 2013·Brain and Cognition·Gershon SpitzJennie L Ponsford
Aug 21, 2013·Journal of the International Neuropsychological Society : JINS·Cristina OmizzoloPeter J Anderson
Jun 3, 2010·Journal of Experimental Psychology. Human Perception and Performance·Andrew Hollingworth, Ian P Rasmussen
Aug 1, 2012·Journal of Experimental Psychology. Learning, Memory, and Cognition·Ashleigh M Maxcey-Richard, Andrew Hollingworth
Sep 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lynn Nadel, Oliver Hardt
Feb 14, 2008·Nature Reviews. Neuroscience·Chris M Bird, Neil Burgess
Jun 10, 2010·Nature Reviews. Neuroscience·Katharina Henke
Jan 21, 2011·Nature Reviews. Neuroscience·Juergen Fell, Nikolai Axmacher
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Nathan CashdollarEmrah Duzel
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nikolai AxmacherJuergen Fell
Jan 18, 2011·Experimental Aging Research·Kaoru Nashiro, Mara Mather
Jun 25, 2010·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Roy P C KesselsMarcel G M Olde Rikkert
Jul 16, 2010·Journal of Neurotrauma·Maja StulemeijerGuillén Fernández
Sep 2, 2008·Brain : a Journal of Neurology·Mischa BraunChristoph J Ploner
Sep 19, 2008·Brain : a Journal of Neurology·Miriam H BeauchampPeter J Anderson
Oct 13, 2006·Cerebral Cortex·Randal A Koene, Michael E Hasselmo
Jul 7, 2007·Cerebral Cortex·Andy C H LeeKim S Graham
Apr 12, 2008·Cerebral Cortex·Nikolai AxmacherJuergen Fell
May 12, 2009·Cerebral Cortex·Helen M MorganDavid E J Linden
Dec 17, 2011·Cerebral Cortex·Morgan D BarenseMary A Peterson
Sep 20, 2012·Cerebral Cortex·Yoshihiro HirataMasahiko Takada
Dec 20, 2011·Learning & Memory·Annette Jeneson, Larry R Squire
Sep 15, 2007·Annual Review of Psychology·John JonidesKatherine Sledge Moore
Sep 15, 2007·Journal of Cognitive Neuroscience·Deborah E HannulaNeal J Cohen
Mar 27, 2009·Journal of Cognitive Neuroscience·Carter Wendelken, Silvia A Bunge
Nov 21, 2009·Journal of Cognitive Neuroscience·Andy C H Lee, Sarah R Rudebeck
May 4, 2010·Journal of Cognitive Neuroscience·Nicole M DudukovicAnthony D Wagner
Jun 16, 2011·Journal of Cognitive Neuroscience·Alan BaddeleyFaraneh Vargha-Khadem
Jul 9, 2011·Journal of Cognitive Neuroscience·David E WarrenNeal J Cohen
Oct 1, 2011·Journal of Cognitive Neuroscience·Jarrod A Lewis-PeacockBradley R Postle
Nov 30, 2006·PLoS Biology·Dharshan Kumaran, Eleanor A Maguire
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yael ShragerLarry R Squire
Aug 10, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dharshan Kumaran, Eleanor A Maguire
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rosanna K OlsenAnthony D Wagner
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annette JenesonLarry R Squire
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deborah E Hannula, Charan Ranganath
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karin FoerdeDaphna Shohamy

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