Workshop overview: reassessment of the cancer risk of dichloromethane in humans

Toxicological Sciences : an Official Journal of the Society of Toxicology
Thomas StarrMelvin E Andersen

Abstract

The U.S. Environmental Protection Agency (U.S. EPA) classifies dichloromethane (DCM) as a "probable human carcinogen," based upon its risk assessment conducted in the late 1980s (http://www.epa.gov/iris/subst/0070.htm). Since that time, cancer risk-assessment practices have evolved, leading to improved scientifically based methods for estimating risk and for illuminating as well as reducing residual uncertainties. A new physiologically based pharmacokinetic (PBPK) model has been developed, using data from human volunteers exposed to low DCM levels, that provides new information on the human to human variability in DCM metabolism and elimination (L. M. Sweeney et al., 2004, Toxicol. Lett. 154, 201-216). This information, along with data from other published human studies, has been used to develop a new cancer risk estimation model utilizing probabilistic methodology similar to that employed recently by U.S. EPA for other chemicals (ENVIRON Health Sciences Institute, 2005, Development of population cancer risk estimates for environmental exposure to dichloromethane using a physiologically based pharmacokinetic model. Final Report to Eastman Kodak Company). This article summarizes the deliberations of a scientific peer-review pane...Continue Reading

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Citations

Feb 18, 2011·International Archives of Occupational and Environmental Health·John A Tomenson
Jun 21, 2011·Journal of Industrial Microbiology & Biotechnology·Nicholas LopesSteven Ripp
Sep 13, 2013·Cancer Causes & Control : CCC·Tao LiuPeng Zhang
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Oct 11, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis·Mitchell J Small
Feb 8, 2011·Journal of Basic Microbiology·Maria L TorgonskayaStéphane Vuilleumier
Apr 4, 2021·Gels·Patrina ParaskevopoulouSotirios Karavoltsos
Aug 22, 2006·Chemical Research in Toxicology·Kengo Watanabe, F Peter Guengerich

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